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168 items found for "conformational dynamics"
- 📰 GPCR Weekly News, June 3 to June 9, 2024
Stay informed with the most recent developments in GPCR research and industry news. Research ORP9-PH domain-based fluorescent reporters for visualizing phosphatidylinositol 4-phosphate dynamics
- Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors
Mapping of Alphafold2 generated models of these proteins confirms that the same sites can be identified Results confirm the possibility of specifically targeting these sites across GPCRs for allosteric modulation
- Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
Therefore, this study aimed to conduct prospective virtual screening and confirm the biological activity To confirm the activity of the virtual hits, an in vitro assay was conducted, measuring cAMP levels at
- 📰 GPCR Weekly News, August 21 to 27, 2023
diseases Methods & Updates in GPCR Research TrGPCR:GPCR-ligand Binding Affinity Predicting based on Dynamic 3rd Annual Meeting IRN I-GPCRNet November 2 - 4, 2023 | GPCR Retreat November 15 - 17, 2023 | MPGPCR Conference 20 - 23, 2023 | ASCEPT Annual Scientific Meeting NEW February 3 - 7, 2024 | SLAS2024 International Conference Recognition and Molecular Gating Seminar NEW March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference Annual PEGS Boston Summit NEW May 16 - 19, 2024 | ASPET 2024 NEW May 27 - 29, 2024 | SLAS Europe 2024 Conference
- 📰 GPCR Weekly News, August 14 to 20, 2023
Share your project in an informal setting with a 1-minute abstract video using this form. Single-molecule analysis reveals that a glucagon-bound extracellular domain of the glucagon receptor is dynamic 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) MPGPCR Conference
- 📰 GPCR Weekly News, February 13 to 19, 2023
The spatial distribution of GPCR and Gβγ activity across a cell dictates PIP3 dynamics. GPCR Events, Meetings, and Webinars SLAS2023 International Conference and Exhibition (February 25 - March (April 20 - 21, 2023) SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. The Illuminating the Understudied Druggable Proteome Conference.
- 📰 GPCR Weekly News, May 27 to June 2, 2024
Stay informed with the most recent developments in GPCR research and industry news. acetylcholine nicotinic receptor heteromer in dopaminergic neurons A new GRAB sensor reveals differences in the dynamics Senior Vice President of Medical Affairs Septerna to Participate in the Jefferies Global Healthcare Conference
- 📰 GPCR Weekly News, April 10 to 16, 2023
Structural and Molecular Insights into GPCR Function Function and dynamics of the intrinsically disordered SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. The Illuminating the Understudied Druggable Proteome Conference.
- 📰 GPCR Weekly News, June 26 to July 2, 2023
GPCRs in Oncology and Immunology Dynamic Phosphoproteomics of BRS3 Activation Reveals the Hippo Signaling
- Novo Nordisk moves to strengthen obesity efforts
Although specific details of the collaboration are yet to be released, EraCal has confirmed that the
- 📰 GPCR Weekly News, February 27 to March 5, 2023
Prepare to stay informed of the most recent findings, developments, and news in the industry. Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist, and stimulatory (April 20 - 21, 2023) SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. The Illuminating the Understudied Druggable Proteome Conference.
- 📰 GPCR Weekly News, July 1 to 7, 2024
For more information, contact us at Hello@DrGPCR.com . ameliorates type 2 diabetes mellitus Methods & Updates in GPCR Research Computational modelling of dynamic
- 📰 GPCR Weekly News, May 13 to 19, 2024
Stay informed and up to date with the latest GPCR research and industry news. revealed by cryo-EM Antibodies expand the scope of angiotensin receptor pharmacology Structural and dynamic 𝐃𝐫𝐮𝐠 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 GPCR Events, Meetings, and Webinars May 27 - 29, 2024 | SLAS Europe 2024 Conference
- 📰 GPCR Weekly News, December 11 to 17, 2023
computational insight on the aromatic amino acids conjugation with [Cp*Rh(H2O)3]2+ by using the meta-dynamics Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International Conference Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference
- Modulation of Striatal Adenosinergic Function by HTL0041178, a Selective GPR52 Agonist
Translational Medicine department, recently presented this important pre-clinical work at SIRS2022 confirming
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell...
techniques were used to analyze β2-AR protein and mRNA levels in a total of 65 histopathologically confirmed
- Label-free LC-MS based assay to characterize small molecule compound binding to cells
October 2022 "Study of small molecule binding to live cells provides important information on the characterization Binding of the probe was confirmed to be specific and saturable, reaching a fast equilibrium.
- Adhesion GPCR Consortium Newsletter - May 2024
This exciting conference will take place from October 23-25th. We'll see you in Mexico City! Please see this website for details on the conference and the Logo Contest! However, Reggaetón is a highly dynamic genre that attracts many here in Mexico, not to forget salsa music
- The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membrane
We confirmed the interaction of VLGR1 with key proteins of MAMs by pull-down assays in vitro complemented
- Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epith
Using shRNA knockdown and CRISPR/Cas9 knockout cell lines, as well as mouse models, we confirmed the
- Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms
We confirmed that this phenomenon of rapidly decreasing agonist-induced GPCR/14-3-3 signal intensity
- A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
NanoBRETTM studies to determine protein–protein interaction were conducted, confirming decreased homodimerization
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
Of these, four fragment- and seven lead-like compounds were confirmed to bind to the allosteric site
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
Of these, four fragment- and seven lead-like compounds were confirmed to bind to the allosteric site
- High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...
Furthermore, univariate analysis confirmed that GPER was a significant prognostic factor for DMFS in
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
These interactions induce local conformational changes which are amplified and transmitted to the intracellular the structure-activity data obtained for the ensemble of candidate hits provides a rich resource of information to inform lead optimization, either by human and in silico-aided rational design, or by the construction For more information, follow Orion Biotechnology on LinkedIn or visit www.orionbiotechnology.com.
- 📰 GPCR Weekly News, December 4 to 10, 2023
For more information click HERE, don’t miss out on this exclusive opportunity! Illuminating the understudied GPCR-ome Industry News Sosei Heptares’ Partner Neurocrine Biosciences Confirms Webinars January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International Conference Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference
- Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent..
We show that epitope-tagged GCGRs undergo clathrin- and dynamin-dependent endocytosis in HEK293 and Huh