mitoxantrone in untreated AML Published date September 12, 2023 Abstract "CC chemokine receptor-3 (hCCR3), a G protein-coupled receptor (GPCR) expressed predominantly on eosinophils, is an important drug target.

cancer-rewired GPCR signaling axes Published date May 8, 2024 Abstract "We explored the dysregulation of G-protein-coupled The expression of both receptor-ligand (or enzymes) partners improved patient stratification, suggesting

feed-forward activation of the SK1-S1P1 signaling axis Published date August 15, 2023 Abstract "The G protein-coupled US28 expression increased the abundance of the key components of the S1P signaling axis, including an

G-protein-coupled receptor class C group 5 member D (GPRC5D), an orphan GPCR predominantly expressed

Regulator of G protein signaling 20 (RGS20) is identified as an upregulated factor in many cancers, yet Methods: Immunohistochemistry and lung cancer tissue microarray were used to verify the expression of Western blotting demonstrated different expressions of autophagy and the Hippo-PKA signal pathway. Results: The higher RGS20 expression was found to be significantly correlated with a poorer five-year

angiostatic activity Published date February 2, 2024 Abstract " Background: Interferon-γ-inducible protein coordinates chemotaxis of activated T cells and natural killer (NK) cells via interaction with its G protein-coupled and through quantification of phosphorylated extracellular signal-regulated kinase-1/2 (ERK1/2) and protein

Friday, November 3rd / 2:10 PM About Karim Ibrahim "A postdoctoral researcher, interested in studying G-protein

Brian Shoichet BSc in Chemistry from MIT, Ph.D. with Tack Kuntz at UCSF; Postdoc with Brian Matthews in protein

Among other projects, I studied the role of β-arrestin in G protein trafficking, the impact of GPCR ubiquitination early tasks at Michelle’s lab, which involved creating stable cell lines and identifying potential protein the potential of multiplexing assays in expanding the scope of scientific exploration and finding new protein Yamina expressed interest in understanding how Badr’s experiences influenced his current role, and Badr Badr expressed interest in broadening his skills beyond the lab, such as project management and effective

We detected BLT2 expression in bone marrow derived and peritoneal macrophages of mouse models. , Titli Nargis , Kierstin Webster , Sarah A Tersey , Ryan M Anderson , Raghavendra G Mirmira Tags G-protein

G-protein-coupled receptors (GPCRs) are the most intensively studied drug targets but are underexplored We also developed transgenic mice expressing a chemogenetic CD8-restricted Gαs-DREADD to activate CD8

US28 is a virally encoded G protein-coupled receptor (GPCR) that is essential for silent infections within to establish a quiescent infection, resulting in a fully productive lytic infection able to produce progeny Inhibiting the dual phosphorylation of Akt prevented the lytic replication of US28Δ, and ectopic expression

With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular

Specifically, I am interested in understanding dysregulated G-protein coupled receptor (GPCR) signaling More recently, I have shifted my focus to identifying allosteric modulators of host G-protein-coupled

Research interests: Signaling mechanisms involving GPCRs and heterotrimeric G proteins" Dr.

research was focused on investigating the cellular effects of missense lung cancer-mutations in the G-protein-coupled

trabecular bone but not fibrosis in a murine model with fibrotic bone Published date May 1, 2024 Abstract "G protein-coupled pathway inhibition , fibrotic bone disease , fibrous dysplasia (FD) , osteoblasts , trabecular bone , G-protein

the different modes of action of Adhesion GPCRs and found that they do not only mediate classical G protein Starting with proving and characterizing G-protein coupling, Ines spends several years studying the activation

the Institute of Pharmacology of Sherbrooke and is an emerging leader in the structural biology of G Protein-Coupled

usually present bilateral benign adrenocortical macronodules at imaging and variable levels of cortisol excess syndrome, but may represent up to one third of bilateral adrenal incidentalomas with evidence of cortisol excess The increased steroidogenesis in PBMAH is often regulated by various G-protein coupled receptors aberrantly expressed in PBMAH tissues; some receptor ligands are ectopically produced in PBMAH tissues creating Treatment is reserved for patients with overt or mild cortisol/aldosterone or other steroid excesses

developing and innovating technologies to solve broad questions in pharmacology, with a specific focus on G-protein

research fellow endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled

Trained as a biochemist, he completed a PhD in protein engineering (Cambridge, UK) with Sir Gregory Winter

GPCR News < GPCRs in Oncology and Immunology Context-dependent ciliary regulation of hedgehog pathway repression Here we determined GLI-A/GLI-R requirements in phenotypes arising from lack of hedgehog pathway repression We studied hedgehog pathway repression by the GPCR GPR161, and the ankyrin repeat protein ANKMY2 that direct cAMP/protein kinase-A signaling by cilia in GLI-R generation. GLI-A formation only, or dual regulation of either lack of GLI-R or excess GLI-A formation.

Slosky’s research is focused on understanding how neuropeptide G protein-coupled receptors (GPCRs) regulate These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling

build Virtual Reality solutions for Scientists and Engineers working at the nanoscale, specifically protein

Instead, he ended up getting interested in membrane protein as he followed the biology of a bacterial

In this episode, Silvio discusses G protein signaling in the context of cancer, immunotherapies, and