In vitro, we used IFNα to stimulate human salivary gland epithelial cells (HSGECs), and the results showed that IFNα activated GRP78-ATF6-CHOP apoptosis signaling, decreased cell viability, and induced apoptosis In addition, β-arrestin2 depletion downregulated GRP78-ATF6-CHOP apoptosis signaling to alleviate cell

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combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis Methods & Updates in GPCR Research Modulating signalling prediction using a protein language model Reviews, GPCRs, and more Potential of olfactory neuroepithelial cells

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In a recent issue of Molecular Cell, Fonseca et al. identified a previously overlooked desensitization

Get ready to share your research with the global GPCR community! 13-coupled designer GPCR GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells Senior Research Associate/Associate Scientist, Protein Science NEW Post-Doctoral Fellow—Pharmacology/Cell

Indicators Design of an effective small expression tag to enhance GPCR production in E. coli-based cell-free and whole cell expression systems A high-throughput structural dynamics approach for identification 2 Study Completes Recruitment of Patients Sanyou Bio's Evolution of Bioprocess Enhancement for CHO Cell

and purpose: Vascular tone is regulated by the relative contractile state of vascular smooth muscle cells

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., combatting the opioid overdose epidemic has become a mean challenge for the scientific community. compartments and their activation is generally related to inhibiting neurotransmission by hyperpolarizing the cell signaling, Shiraki et al., explored the function of β-arrestin 2 in MOR signaling using the SH-SY5Y cell Biochem Biophys Res Commun. 2023 Jan 15;640:64-72. doi: 10.1016/j.bbrc.2022.11.098.

Sukhtankar and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic cells -100), a Novel C-X-C Chemokine Receptor 4 Antagonist and Mobilizer of Hematopoietic Stem/Progenitor Cells Research Collaboration Addex Therapeutics To Release Half-Year 2023 Financial Results And Host Conference Call

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human neutrophil expressed formyl peptide receptors GPCRs in Cardiology, Endocrinology, and Taste Beta cell 5 and 6 axis prevents diabetic cardiomyopathy in mice GPCRs in Neuroscience Coexistence within one cell revealed by structural pharmacology Industry News The Adrenaline Puzzle Solved: Scientists Untangle Key Cell

produced “on demand” to finely regulate the synthesis and secretion of hormones and neurotransmitters, as well It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt not only the hypothalamic–pituitary–adrenal axis but also

Justin English on "Empowering Drug Discovery for the GPCR Community"! Scientist Senior Research Associate/Associate Scientist, Protein Science Post-Doctoral Fellow—Pharmacology/Cell

Regulation of Cardiomyocyte Rac1 Signaling Activity and Minor Effects on Cardiac Hypertrophy Single cell Immunology Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways Spliceosome mutations are associated

regulate receptor phosphorylation and signaling termination, GRK2, which is highly expressed by immune cells The medium chain fatty acid receptor GPR84 as well as formyl peptide receptor 2 (FPR2), receptors expressed

properties have driven the need for development of specialized tools that can sense neuropeptide expression, cell Current research has focused on isolating when and how neuropeptide transmission occurs, as well as the

podocytopathy in kidney disease Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid cells with advanced gastroenteropancreatic neuroendocrine tumors Neurocrine Biosciences Announces Conference Call

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have a poster session in breakout rooms on Zoom; if you are interested in sharing your work with our community You'll share your contributor articles with the community, stay updated with GPCR literature, join a Endocrinology, and Taste The Role of G Protein-Coupled Receptors and Receptor Kinases in Pancreatic β-Cell ended 31 December 2023 Pioneering Research in GPCR Pharmacology: Unraveling the Secrets of Cellular Communication Bowes Biomedical Investigator Takes Aim at Cracking Cellular Communication Code Aelis Farma will be

as part of their strategy to escape immune surveillance, promote virus spreading, or reprogram host cells

of HH, the second effect of FU leads to the local enrichment of SMO in the most basal domain of the cell

activity in the cortex of anesthetized mice and displays illumination-dependent activity in individual cells

Using CRISPR-Cas9 knockout HEK cells lacking Gs proteins, a study by Stallaert et al. in 2017 showed Receptor Transactivation by the β(2)-Adrenergic Receptor Increases Intracellular Ca(2+) in Nonexcitable Cells

Expression of GPR84 is strongly up regulated in immune cells in a range of pro-inflammatory settings

September 2022 "Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular