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276 items found for "Cell cycle"
- Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses
as part of their strategy to escape immune surveillance, promote virus spreading, or reprogram host cells
- Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84
Expression of GPR84 is strongly up regulated in immune cells in a range of pro-inflammatory settings
- Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
Using CRISPR-Cas9 knockout HEK cells lacking Gs proteins, a study by Stallaert et al. in 2017 showed Receptor Transactivation by the β(2)-Adrenergic Receptor Increases Intracellular Ca(2+) in Nonexcitable Cells
- Isoform-and ligand-specific modulation of adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
September 2022 "Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular
- 📰 GPCR Weekly News, January 22 to 28, 2024
Comparative interactome analysis of α-arrestin families in human and Drosophila Functional diversification of cell in Cardiovascular Health and its Therapeutic Implications The perspective of cAMP/cGMP signaling and cyclic of Gi-coupling receptors via engineered Gt and Nb35 application Imaging GPCR Dimerization in Living Cells
- 📰 GPCR Weekly News, May 6 to 12, 2024
The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell in a murine model with fibrotic bone The orphan G protein-coupled receptor 141 expressed in myeloid cells pathway networks as cancer therapeutic targets Generation of comprehensive GPCR-transducer-deficient cell
- Cholesterol occupies the lipid translocation pathway to block phospholipid scrambling by a GPCR
Yet phospholipid scrambling is not detectable in the resting plasma membrane of mammalian cells that
- Opioid Receptors and Protonation-Coupled Binding of Opioid Drugs
Opioid receptors are G-protein-coupled receptors (GPCRs) part of cell signaling paths of direct interest
- 📰 GPCR Weekly News, June 19 to 25, 2023
induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells GPCR Events, Meetings, and Webinars Training School on “Cell-based assays to study Adhesion GPCR function
- Nanobodies as Probes and Modulators of Cardiovascular G Protein-Coupled Receptors
camelids, have become indispensable tools for interrogating GPCRs both in purified systems and in living cells
- The microglial endocannabinoid system similarly regulated by lipopolysaccharide and interferon gamma
Microglia are one of few cell types with a self-contained endocannabinoid system and are positioned at
- Location bias contributes to functionally selective responses of biased CXCR3 agonists
In CD8 + T cells, the chemokines promote unique transcriptional responses predicted to regulate inflammatory
- Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
By means of these studies, we developed 14 as a fluorescent CCR2 ligand, enabling cell-free as well
- Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior...
We discuss the importance of understanding the translatability of cell and animal models to have more
- Job Opportunity Spotlight #1: Principal Scientist, In Vitro Pharmacology
Someone with strong assay development skills as well as strong data analysis and interpretation skills Beth: “We focus on biochemical, cell based, and radioligand binding assays to enable SAR, MOA, lead Top candidates will have a solid foundation in GPCR pharmacology as well as some experience in drug discovery Beth: “Well, I enjoy training and mentoring team members.
- 📰 GPCR Weekly News, May 22 to 28, 2023
Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells 2023) NEW GPCRs in drug discovery: challenges & solutions (June 19 - 23, 2023) Training School on “Cell-based
- 📰 GPCR Weekly Buzz: Exciting Schedule Shifts for Principles of Pharmacology I & II | August 12-18, 2024
Endocrinology, and Taste Regulator of G-protein signaling expression in human intestinal enteroendocrine cells , 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based
- 📰 GPCR Buzz: August 5-11, 2024 | Top Highlights from DrGPCR University!
Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell-derived , 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based
- Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent..
epitope-tagged GCGRs undergo clathrin- and dynamin-dependent endocytosis in HEK293 and Huh-7-Lunet cells
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
Here, we discovered that the epithelial-cell-derived antimicrobial peptides defensins activated orphan
- 📰 GPCR Weekly News, July 17 to July 23, 2023
Submit a 1-minute abstract video and tell us more about your project in this form. Drosophila homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells GPCRs in Oncology and Immunology A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure
- Drug Discovery Picks Up the Pace, Stays on Target
small molecules that conditionally modulate proteins in their functional state; three-dimensional (3D) cell
- 📰 GPCR Weekly News, June 24 to 30, 2024
Translation-independent association of mRNAs encoding protomers of the 5-HT 2A -mGlu2 receptor complex in living cells radiopharma play GPCR Events, Meetings, and Webinars September 18, 2024 | FREE Webinar - The value of GPCR cell-based
- Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
They participate in the activation, chemotaxis and recruitment of multiple immunological cells such as
- Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...
nab-paclitaxel has shown clinical activity in advanced TNBC with PD-L1-positive tumor-infiltrating immune cells
- 📰 GPCR Weekly News, December 4 to 10, 2023
G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell neuroscience drugmaker Cerevel Therapeutics for $8.7 billion FDA approves two gene therapies for sickle cell
- Pepducin-mediated G Protein-Coupled Receptor Signaling in the Cardiovascular System
vary between antagonist, partial agonist, and biased agonist outcomes in various primary and clonal cell We will discuss the historic context of pepducin development for each receptor, as well as the structural
- Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated
Here we investigated a potential mechanism for regulation of PLC signaling downstream of MOR in HEK293 cells