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272 items found for "Cell proliferation"
- GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting
regulate receptor phosphorylation and signaling termination, GRK2, which is highly expressed by immune cells The medium chain fatty acid receptor GPR84 as well as formyl peptide receptor 2 (FPR2), receptors expressed
- Emerging approaches for decoding neuropeptide transmission
properties have driven the need for development of specialized tools that can sense neuropeptide expression, cell Current research has focused on isolating when and how neuropeptide transmission occurs, as well as the
- Nanobodies: New Dimensions in GPCR Signaling Research
They have also been used as biosensors to monitor conformational changes of GPCRs in living cells. Most Nbs can be functionally expressed as genetically encoded intrabodies within a eukaryotic cell. correlating structural or dynamic features observed in vitro with functional observations from living cells
- 📰 GPCR Weekly News, January 15 to 21, 2024
podocytopathy in kidney disease Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid cells with advanced gastroenteropancreatic neuroendocrine tumors Neurocrine Biosciences Announces Conference Call
- 📰 GPCR Weekly News, April 17 to 23, 2023
FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Scientist - Antibody Engineering Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based
- Enhancing GPCR Research Outreach | Dr GPCR University early-bird registration ends soon!
clytin II: Expression of the preferred human codon-optimized clytin II gene in Chinese hamster ovary-K1 cells the Drug Discovery Ecosystem Summit Tectonic Therapeutic Announces Closing of Merger with AVROBIO as well Program, TX45 GPCR Events, Meetings, and Webinars September 18, 2024 | FREE Webinar - The value of GPCR cell-based
- High hedgehog signaling is transduced by a multikinase-dependent switch controlling the...
of HH, the second effect of FU leads to the local enrichment of SMO in the most basal domain of the cell
- Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals
activity in the cortex of anesthetized mice and displays illumination-dependent activity in individual cells
- Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses
as part of their strategy to escape immune surveillance, promote virus spreading, or reprogram host cells
- Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84
Expression of GPR84 is strongly up regulated in immune cells in a range of pro-inflammatory settings
- Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
Using CRISPR-Cas9 knockout HEK cells lacking Gs proteins, a study by Stallaert et al. in 2017 showed Receptor Transactivation by the β(2)-Adrenergic Receptor Increases Intracellular Ca(2+) in Nonexcitable Cells
- Isoform-and ligand-specific modulation of adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
September 2022 "Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular
- 📰 GPCR Weekly News, May 6 to 12, 2024
The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell in a murine model with fibrotic bone The orphan G protein-coupled receptor 141 expressed in myeloid cells pathway networks as cancer therapeutic targets Generation of comprehensive GPCR-transducer-deficient cell
- Cholesterol occupies the lipid translocation pathway to block phospholipid scrambling by a GPCR
Yet phospholipid scrambling is not detectable in the resting plasma membrane of mammalian cells that
- Opioid Receptors and Protonation-Coupled Binding of Opioid Drugs
Opioid receptors are G-protein-coupled receptors (GPCRs) part of cell signaling paths of direct interest
- 📰 GPCR Weekly News, June 19 to 25, 2023
induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells GPCR Events, Meetings, and Webinars Training School on “Cell-based assays to study Adhesion GPCR function
- Nanobodies as Probes and Modulators of Cardiovascular G Protein-Coupled Receptors
camelids, have become indispensable tools for interrogating GPCRs both in purified systems and in living cells
- The microglial endocannabinoid system similarly regulated by lipopolysaccharide and interferon gamma
Microglia are one of few cell types with a self-contained endocannabinoid system and are positioned at
- Location bias contributes to functionally selective responses of biased CXCR3 agonists
In CD8 + T cells, the chemokines promote unique transcriptional responses predicted to regulate inflammatory
- Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
By means of these studies, we developed 14 as a fluorescent CCR2 ligand, enabling cell-free as well
- Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior...
We discuss the importance of understanding the translatability of cell and animal models to have more
- Job Opportunity Spotlight #1: Principal Scientist, In Vitro Pharmacology
Someone with strong assay development skills as well as strong data analysis and interpretation skills Beth: “We focus on biochemical, cell based, and radioligand binding assays to enable SAR, MOA, lead Top candidates will have a solid foundation in GPCR pharmacology as well as some experience in drug discovery Beth: “Well, I enjoy training and mentoring team members.
- 📰 GPCR Weekly News, May 22 to 28, 2023
Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells 2023) NEW GPCRs in drug discovery: challenges & solutions (June 19 - 23, 2023) Training School on “Cell-based
- 📰 GPCR Weekly Buzz: Exciting Schedule Shifts for Principles of Pharmacology I & II | August 12-18, 2024
Endocrinology, and Taste Regulator of G-protein signaling expression in human intestinal enteroendocrine cells , 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based
- 📰 GPCR Buzz: August 5-11, 2024 | Top Highlights from DrGPCR University!
Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell-derived , 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based
- Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent..
epitope-tagged GCGRs undergo clathrin- and dynamin-dependent endocytosis in HEK293 and Huh-7-Lunet cells
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
Here, we discovered that the epithelial-cell-derived antimicrobial peptides defensins activated orphan
- 📰 GPCR Weekly News, July 17 to July 23, 2023
Submit a 1-minute abstract video and tell us more about your project in this form. Drosophila homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells GPCRs in Oncology and Immunology A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure