GPCR Podcast << Back to podcast list Dr. David E. of Copenhagen where he leads a research cluster for GPCR function and drug discovery and a Pharmaceutical protein-coupled receptors. probes for a range of receptors. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand

protein coupled receptor GPR101 mediates the phagocyte-directed pro-resolving activities of RvD5n-3 DPA Herein, we investigated the endogenous role of this pro-resolving receptor in modulating macrophage biology in the expression of phenotypic and activation markers, including the Interleukin (IL)-10 and IL-23 receptors papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology

GPCR Podcast << Back to podcast list Martin Audet About Dr. the Institute of Pharmacology of Sherbrooke and is an emerging leader in the structural biology of G Protein-Coupled Receptors and passive transporters. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand

by protein kinase C. Robert Lefkowitz , which led to the finding that both β-arrestin and G protein can simultaneously bind to some GPCRs when signaling in endosomes by forming a megaplex. Funded by a Wellcome Trust Seed Award, she investigated biased and compartmentalized G protein signaling by the vasopressin type 2 receptor.

GPCR Podcast << Back to podcast list Dr. Timo De Groof About Dr. Timo De Groof Dr. protein-coupled receptors with a special focus on the human cytomegalovirus-encoded chemokine receptor in multiple projects where he focuses on the generation of nanobodies against "difficult-to-target" proteins In the near future, Timo hopes to combine his previous GPCR experience with his current focus to set up his own research line focusing on translational applications of GPCR-targeting nanobodies.

GPCR Podcast << Back to podcast list The Role of Quantitative Sciences in GPCRs with Dr. Following her postdoctoral studies on protein dynamics simulation methods at University of Southern California contributions in developing constrained molecular dynamics simulation methods with emphasis on application to G-protein coupled receptors and drug design." GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs

schedule Regulation and role of mitochondria delta opioid receptors Date & Time Friday, November 3rd where he used various approaches to describe the role of opioid receptors in pain and anagesia as well as to study the mechanisms involved in the cellular trafficking of the delta opioid receptor. potential proteins interacting with GPCRs. 22nd GPCR Retreat Sponsored by

mesenchymal transition of glioblastoma Published date November 19, 2023 Abstract "G protein-coupled receptor 56 (GPR56/ADGRG1) is a multifunctional adhesion GPCR involved in diverse biological processes The map incorporates more than 100 molecular entities including kinases, receptors, ion channels, and GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

approaches to quantify ligand bias and the identification of ACKR3 as an endogenously beta-arrestin-biased receptor His group and others have shown that many of these ligands act as biased agonists for the same receptor formation of complexes between G proteins and beta-arrestins. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by

Axel Brunger’s lab at Stanford University to study the structure and function of cell-adhesion proteins (G protein-coupled receptor). meeting, and the naming conventions of proteins in the field. research in the GPCR (G protein-coupled receptor) field, specifically focusing on adhesion GPCRs. They also discussed the importance of the extracellular region of these receptors and its potential as

GPCR Podcast << Back to podcast list Dr. G. Aditya Kumar About Dr. G. Aditya Kumar Dr. at Hyderabad, India, where he studied the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling and endocytosis. , subcellular trafficking, and membrane biology to better understand how the dynamic receptor microenvironment contributes to GPCR organization and function.

< GPCR News < GPCRs in Oncology and Immunology CaaX-motif-adjacent residues influence G protein gamma Prenyltransferases tether isoprenoid lipids to proteins via a thioether linkage during prenylation. Building on our previous finding that statins inhibit membrane association of G protein γ (Gγ) in a subtype-dependent protein signaling in cells depending on their Gγ-subtype composition. & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

GPCR Podcast << Back to podcast list Dr. Nicholas Holliday About Dr. and the immune system, and the molecular mechanisms underlying the signaling and regulation of their GPCRs protein-coupled receptor kinetics, signaling, and trafficking and on using novel imaging techniques, Excellerate is involved in several pre-clinical drug discovery projects for both GPCR and non-GPCR targets GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand

GPCR Podcast << Back to podcast list Dr. Adriano Marchese About Dr. protein-coupled receptor trafficking and signaling. His lab has shown a role for -arrestins and PTMs in GPCR trafficking and signaling and has leveraged The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand

GPCR Podcast << Back to podcast list Dr. Paul Insel About this episode In 1975, Dr. Alfred Gillman , co-recipient of the 1994 Nobel Prize in Physiology or Medicine for their discovery of G-proteins From that point on, Paul was hooked and has since studied receptor function in human physiology, receptor pharmacology in cells, and animal models, and as he puts it has now he’s "gone full circle" back to studying GPCRs GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand

protein-coupled receptor (Gi-GPCR) neurons and neuropeptide changes. Progressive neuroinflammation spreads after injury, and neurotransmission through Gi-mediated G protein-coupled receptors in the HPA axis and neuropeptide production by the hypothalamus are inhibited. GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

facilitates leukocyte adhesion by interacting with cell surface-expressed CXCL16 and plays a key role in G-protein selectivity during receptor signalling; however, our findings show that this motif is not universal. These substitutions at the DRF motif affect the receptor-Gi/o protein interaction. Authors Buddhabhushan Girish Salve, Sandhya Sharma, Nagarjun Vijay Tags ITGAE , Chemokine receptors , papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more

GPCR Podcast << Back to podcast list Dr. Thomas P. Sakmar About Dr. Thomas P. also went on to discover a “counterion switch” in visual pigments and to develop strategies to assay receptor-G-protein from this work, such as the concept of “functional micro-domains” and the “helix movement model of receptor photo-crosslinking,” and more recently, the parallel development of bioorthogonal labeling strategies to couple fluorophores to expressed receptors and other membrane proteins has allowed the creation of novel sensor

< GPCR News < GPCRs in Oncology and Immunology Structural Basis for the Recognition of GPRC5D by Talquetamab G-protein-coupled receptor class C group 5 member D (GPRC5D), an orphan GPCR predominantly expressed Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to protein-coupled receptors is increasingly recognized as an important immune checkpoint in the generation GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

signaling by the receptors CCR1 and CCR5 Published date November 23, 2023 Abstract "Inflammatory chemokines elevated in disease settings, where the largest group of CC-chemokines are the macrophage inflammatory proteins (MIP), which are promiscuous for the receptors CCR1 and CCR5. GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

< GPCR News < GPCRs in Oncology and Immunology Purinergic GPCR-integrin interactions drive pancreatic Mediated in part by highly druggable extracellular proteins, this axis plays essential roles in fibrosis pharmacological strategies we demonstrate mechanistically that this ATP-driven invasion requires direct protein-protein Moreover, receptor-integrin interactions were required for effective downstream signalling, leading to papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more

receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach Published date November 27, 2023 Abstract "Somatostatin receptors are clinically validated GPCR biomarkers for Among the five somatostatin receptors, SST2 and SST3 are associated with apoptosis and cell cycle arrest , making these receptor subtypes better differentiated targets in precision oncology. The expression prevalence of both receptors tends to decline with tumor progression.

< GPCR News < GPCRs in Oncology and Immunology Opposite Effects of Src Family Kinases on YAP and ERK Previously, we identified potent positive crosstalk between insulin/IGF-1 receptors and G protein-coupled News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

GPCR Podcast << Back to podcast list Dr. Kathleen Caron About Kathleen M. Caron Kathleen M. With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular

GPCR Podcast << Back to podcast list Dr. Sudarshan Rajagopal About Dr. Sudarshan Rajagopal Dr. His group and others have shown that many of these ligands act as biased agonists for the same receptor His lab is also interested in identifying novel signal transduction mechanisms of GPCRs, such as the formation of complexes between G proteins and beta-arrestins. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand

< GPCR News < GPCRs in Oncology and Immunology From odor to oncology: non-canonical odorant receptors Alongside the canonical GPCR odorant receptors, dysregulation of non-canonical odorant receptors such as trace amine-associated receptors (TAARs), formyl peptide receptors (FPRs), and membrane-spanning a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs in Oncology and

Receptor data shows how GPCR control of cellular function goes far beyond simple second messenger production Lecture 3: The Application of GPCR Ligand Kinetics to Candidate Design. Lecture 4: Unconventional GPCR Ligands as Drugs. Lecture 5: Unique Exploitable GPCR-Ligand Behaviors for Therapeutic Benefit. My interests are in receptor theory, pharmacology applied to drug discovery and allosteric protein function