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215 items found for "Lauren T May"
- GPCR Buzz of the Week | Sep 23 - 29, 2024
You Should Enroll Now: Budget-Friendly & Distinctive Educational Experience Affordable courses that maintain
- Transformative GPCR Insights: Unleash New Horizons in Science | Sep 9 - 15, 2024
You Should Enroll Now: Cost-effective & Distinctive Educational Experience Affordable courses that maintain
- Unlock the Future of GPCR Science: Breakthroughs and Courses Await | Sep 2 - Sep 8, 2024
Latrophilin-1 controls multiple processes in reproduction of C. elegans The G protein-coupled receptor ADGRG6 maintains
- APEX2/AUR Biosensor: A Powerful Tool for Protein Interaction and Trafficking
research could inform the development of safer analgesics that minimize the risk of addiction while maintaining
- Unlocking the Future of Medicine: Advancements in GPCR Research
Conformational dynamics underlying atypical chemokine receptor 3 activation RhoA-mediated G12-G13 signaling maintains
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
remain inactive in the absence of endogenous orthosteric activity, therefore having the potential to maintain
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
remaining non-sensory receptors, with functions more readily linked to pathology, are currently the main
- Overview of adhesion GPCRs self-activation
with Gs, Gi, Gq, and G12, where like other GPCRs, the distal αH5 region of the G protein was needed to maintain
- Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery
the dimerization interface is affected by the activation state of the receptors, with the interface mainly located at TM4 and TM5 when mGluR2 dimers are inactive, switching to an interface mainly at TM6 when
- Therapeutic validation of an orphan G protein‐coupled receptor
GPR84 is a Gi‐coupled class A GPCR mainly expressed in immune cells and microglia in the brain (Wojciechowicz
- TM5-TM6: structural switches that modulate the coupling of serotonin receptors to Gs or Gi
These differences are mainly attributed to the characteristic Ras domain distance between Gs and Gi.
- Ode to GPCRs
Moreover, the G protein-independent pathway is mainly regulated by arrestin, which recognizes and binds Mayo Clinic proceedings. Mayo Clinic 68, 262 (1993). https://doi.org/10.1016/S0025-6196(12)60046-9/. 19.
- The Gluopsins: Opsins without the Retinal Binding Lysine
The gluopsins are mainly dragonfly and butterfly opsins, closely related to the RGR-opsins and the retinochromes
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
The mGlu5 receptor is activated by the main excitatory neurotransmitter of the nervous central system
- Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone...
increasing prevalence of obesity and type 2 diabetes (T2DM) is provoking an important socioeconomic burden mainly Moreover, the main investigations into animal models and ongoing clinical trials using these unimolecular
- Adrenal G Protein-Coupled Receptors and the Failing Heart: A Long-distance, Yet Intimate Affair
which block the effects of angiotensin II (AngII) and aldosterone on the failing heart, are part of the mainstay
- Specific Functions of Melanocortin 3 Receptor (MC3R)
In this review paper, we aimed to point out the importance of the MC3R regulations in three main concepts
- Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental...
protein-coupled receptors in placental development and preeclampsia "Preeclampsia, a clinical syndrome mainly
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection "Healthy skin maintains study demonstrated the importance of epithelial-neutrophil signaling via the defensin-Mrgpra2 axis in maintaining
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
The mGlu5 receptor is activated by the main excitatory neurotransmitter of the nervous central system
- Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias...
arrhythmias and disrupts the fine-tuning of Gi/o signaling "Aims: Cardiac contractility, essential to maintaining Whether RGS2 and 5 redundantly control G protein signaling to maintain cardiovascular homeostasis is
- Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
bind the receptor through both hydrophobic and polar interaction, while Gi/G12/G13 engage receptor mainly
- Structural view of G protein-coupled receptor signaling in the retinal rod outer segment
system highlights the potential roles of phosphodiesterase 6 (PDE6) and guanylate cyclases (GCs) in maintaining
- Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
October 2022 "CXCR1 and CXCR2 chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8),
- Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
August 2022 "CXCR1 and CXCR2 chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8),
- GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal...
These results suggest that GPR3 expression in RGCs helps maintain neuronal survival and accelerates axonal
- Multifunctional role of GPCR signaling in epithelial tube formation
We also report on unexpected Fog-independent roles for Smog in maintaining epithelial integrity and organizing
- Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR..
free-energy landscape of the ligand-receptor binding by searching large-scale motions accompanied with stable maintenance