2024) GPCR Jobs NEW Director, Regulatory Affairs NEW Research Scientist/Senior Scientist I - Molecular Pharmacology

2024 | 9th GPCRs in Medicinal Chemistry July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

existence as homo and herero-oligomeres at the cell surface should be considered when assessing the pharmacological

Annual review of pharmacology and toxicology, 57, 19–37. https://doi.org/10.1146/annurev-pharmtox-010716

chemical synthesis using Orion’s proprietary multiplex synthesis technology, and then screened for pharmacological in industry, and one that is uniquely capable of generating drug candidates with optimal molecular pharmacological Orion has world-renowned expertise in GPCR pharmacology and protein engineering, and its proprietary

greatly impact not only the way we understand how aGPCR works but might also provide a guide to how pharmacological

August 2022 "WELCOME 4GPCRnet meeting bringing together four of the biggest GPCR networks in Europe for Four of the biggest European networks on GPCR research (COST Actions Adher’n Rise and ERNEST plus DFG-funded

formulate strategies to help modulate the activation and signaling of these receptors, particularly with a pharmacological

The differentially expressed genes (DEGs) and weighted correlation network analysis (WGCNA) were performed using R software, and functional enrichment analysis and protein–protein interaction (PPI) network were

SEPTEMBER 26-29, 2022 (Leipzig, Germany)​ 4GPCRnet meeting bringing together four of the biggest GPCR networks Four of the biggest European networks on GPCR research ( COST Actions Adher’n Rise and ERNEST plus

Innovative structural biology techniques, pharmacological methods, state-of-the-art biosensors, supplementary

Dynamic network analysis further reveals that Nb80 binding triggers tighter and stronger local communication networks between the Nb80 and the ligand-binding sites, primarily involving residues around ICL2 and

Collectively, these findings reveal a unique hydrogen-bonding network located on intracellular loop 2

GPCR trafficking and signaling, and they connect a large number of diverse proteins to form signaling networks

Pharmacol Rev, 2002. 54(3): p. 527-59. https://pubmed.ncbi.nlm.nih.gov/12223533/ 4. Wang, Q., L.Y.

Furthermore, the community network analysis suggests that the palmitoylation of Go not only allosterically

structures in the prefrontal cortex and amygdala, which were previously linked to the brain salience network

as a prototypic class B GPCR target, and a combination of molecular dynamics simulations and elastic network

expression and RNA-Seq analyses revealed specific LAT-1-positive neurons and first insights into the genetic network

AlphaFold, RoseTTAFold and Modeller: a case study involving the use of G-protein-coupled receptors "Neural network

modify macrophage susceptibility to Hc infection, greatly expanding our understanding of host gene networks

In this article, we hypothesized that the chemokine/chemokine receptor axes network have crucial and

Chemical communication controls a wide range of behaviors via conserved signaling networks.

Conformational changes between inactive and active states are facilitated by a "microswitch network" As a result of the unique active conformation, the residues in the microswitch network show non-canonical share a glutamine residue at the "toggle switch" position 6.48 and the disruption of a hydrogen-bond network

CCR2 was also shown to be resistant to degradation and most likely recycling through the trans-Golgi network

Nicola Smith, Molecular Pharmacologist, lab head, and senior lecturer at UNSW Sydney.