)[6] and GLP-1R [7], while GLP-1R is also known to heterodimerize with the GIPR in recombinant cell system

powerful applications of new cellular assays to determine GPCR ligand behavior in different functional systems

GPCRs in Oncology and Immunology CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment

propranolol Discovery of 3-Phenyl Indazole-Based Novel Chemokine-like Receptor 1 Antagonists for the Treatment

GPCRs in Cardiology, Endocrinology, and Taste Discovery of paralogous GnRH and corazonin signaling systems

species with an engineered sensor A Multi-Angle Approach to Predict Peptide-GPCR Complexes: The N/OFQ-NOP System

Drugs, and more Elucidation of active components and target mechanism in Jinqiancao granules for the treatment

Announces Positive Initial Findings at ENDO 2024 for Atumelnant in Two Ongoing, Open-Label Studies for the Treatment

Loss of biased signaling at a G protein-coupled receptor in overexpressed systems.

analysis Industry News Boehringer Ingelheim and Sosei Heptares join forces to develop first-in-class treatments

GPCR-targeted drug development in dermatology Advances in small-molecule insulin secretagogues for diabetes treatment

receptor, forms oligomers GPCR Activation and Signaling Unraveling the crosstalk between renin-angiotensin system

in yeast Reviews, GPCRs, and more Class B1 GPCRs: Insights into Multi-Receptor Pharmacology for the Treatment

interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment

Reviews, GPCRs, and more Internal and external modulation factors of the orexin system (REVIEW).

Precision medicines for GPCRs: AI can facilitate the development of personalized treatments by analyzing patient data, including genomic information, clinical records, and treatment outcomes.

Mechanism of Action and Target Engagement Novo Nordisk's GLP-1 for Type II diabetes approved for first-line treatment

Quantitative studies of how drugs modulate their targets have been instrumental in discovering new treatments

Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System

and more Network pharmacology -based study on the mechanism of traditional Chinese medicine in the treatment

Grants Fuel Exciting GPCR and Signaling Protein Research Tools First-In-Class Drug Shows Potential for Treatment

From these series of compounds, GLPG1205 progressed into clinical development for the potential treatment

receptor GPCRs in Cardiology, Endocrinology, and Taste Discovery of a SUCNR1 antagonist for potential treatment

through phenotypic profiling in C. elegans Reviews, GPCRs, and more Classifying tetraspanins: A universal system

GPCRs in Cardiology, Endocrinology, and Taste Targeting G Protein-Coupled Receptors for Heart Failure Treatment

axes in ALS pathophysiology Common changes in rat cortical gene expression after antidepressant drug treatment

Activity Models of Key GPCR Families in the Central Nervous System: A Tool for Many Purposes.

Novartis Lutathera® significantly reduced risk of disease progression or death by 72% as first-line treatment