August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide

One potential solution is to develop analgesics that act at targets other than opioid receptors.

activated by an oxysterol ligand and will facilitate the development of therapeutic approaches that target

August 2022 "Despite the importance of members of the GPCR superfamily as targets of a broad range of

Dipraglurant selectively targets the metabotropic glutamate receptor subtype 5 (mGlu5) through allosteric

, CX3CR1 binds to its sole endogenous ligand CX3CL1, which shows notable potential as a therapeutic target

functions using unique tools, and thus establishes a foundation for the development of fine-tuned aGPCR-targeted

diseases, and understanding the mechanisms of these complex molecules is crucial for developing effective therapies Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target

However, many new targets, such as Mas-related GPCRs and unexpected new pathways need to be also explored

Stay tuned for our next symposium on GPCRs as Therapeutics Targets on October 11th, 2024. regulation of the glucagon receptor family Technologies for the discovery of G protein-coupled receptor-targeting inflammation, resolution and beyond Exploring GPCR signaling pathway networks as cancer therapeutic targets

These molecules are then evaluated at unprecedented speed and scale on hundreds of GPCR targets simultaneously

Understanding real-time kinetics to predict activity and in vivo target coverage. Europe   November 25 - 27, 2024 | 1st Virtual GPCR Forum Conference November 26 - 28, 2024 | GPCRs-Targeted

cardiovascular medicine due to the critical physiological roles of these receptors and their prominence as drug targets

critical to the overall biased response observed at CXCR3, which has important implications for drugs targeting

The potentially low pH at tissue targeted by opioid drugs in pain management could impact drug binding

biochemical, cell based, and radioligand binding assays to enable SAR, MOA, lead optimization, and new target

However, how these states impact GPCRs biological function and therapeutic targeting remains incompletely

importance of understanding the translatability of cell and animal models to have more precise functional targeting

inflammation is a hallmark of refractory chronic rhinosinusitis (CRS) and considered a major therapeutic target in myeloid cells plays a causal role in eosinophilic CRS (ECRS) via macrophage IL‐1β overproduction, thereby

homeostasis of the ocular surface, alterations in disease settings, and the possible therapeutic potential of targeting

Allosteric activation of the ERK MAPK by β-arrestin GPCR Binders, Drugs, and more Pharmacologically targeting intracellular allosteric sites of GPCRs for drug discovery Targeting mGluR group III for the treatment

have shown PI(4,5)P2 interacting with the Glucagon receptor (GCGR), which constitutes an important target

GPCR contributor article Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted Preclinical Data from GPCR Drug Discovery Engine at ENDO 2024 The Promise of Oxytocin: Novel Approaches for Targeting

is needed to unravel TRPM3's full potential as experimental tool, diagnostic marker and therapeutic target

Results confirm the possibility of specifically targeting these sites across GPCRs for allosteric modulation

Disorders at Jefferies Healthcare Conference in London Sosei Heptares and Kallyope Nominate First GPCR Target 3 - 7, 2024 | SLAS2024 International Conference and Exhibition NEW March 5 - 7, 2024 | 3rd GPCRs - Targeted

autophagy and the CDKN1B-CDK2-CCNE1-E2F1 axis and indicate that ARRB1 may be a potential therapeutic target microtubule associated protein 1 light chain 3 beta; MKI67: marker of proliferation Ki-67; MTOR: mechanistic target

GPCR Binders, Drugs, and more An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit, (February 21 - 23, 2023)