August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide

This review delivers a concise overview of the role of β-arrestins with a primary emphasis on the signaling

electrophysiological recordings to evaluate the effects of YM-254890 on the excitability of dorsal root

We found that preincubation and luminescence reading at room temperature were optimal as compared to

However, the potential role of GPR3 in axonal regeneration after neuronal injury has not been elucidated

This article focuses on the role of Aβ granules and their possible interaction with GPCRs that modulate

α9β1, associate with elevated blood pressure; however, neither SVEP1 nor integrin α9β1 has reported roles

GRK2/β-arrestin2 play multiple roles in the pathological mechanisms of a wide range of diseases including This review summarizes the roles of GRK2/β-arrestin2 in immune cell function and focuses on the pathological

Although some G-protein coupled receptors (GPCRs) were reported to play roles in osteoblast function, little is known about the roles in osteoclasts. But GPR110 knockout and subsequent rescue experiments revealed a pivotal role of GPR110 in the attenuation

Here, we sought to investigate the role of Regulator of G Protein Signaling 7 (RGS7) in hyperlipidemia-dependent

In this study, we aimed to explore the role of TAS2R in odontoblastic differentiation of hDPSCs in the

The aim of this study was to evaluate the role of GPR21 in human macrophages, analyzing (i) its involvement

fluorescently tagged histamine, we explored H2R-histamine binding interaction, which exhibits a critical role

phosphorylation and signaling termination, GRK2, which is highly expressed by immune cells, plays an important role receptor GPR84 as well as formyl peptide receptor 2 (FPR2), receptors expressed in neutrophils, play a key role

Our data support the idea of a modulatory role of anosmin 1 in the biological effects controlled by the

Nicholas Holliday and how he has combined his university role with his leadership of Excellerate Bioscience

Although the vital role of ACs in cellular signalling is well established, the function of their transmembrane

Although increasing evidence has suggested the direct role of fentanyl on cancer, little is known on

However, controversy remains regarding its role in breast cancer since both pro- and anti-metastatic roles have been ascribed to it.

appears to be context-dependent compared to the C5aR1, which has received enormous attention for its role

This review discusses the specific tissue expression of the components of the chemerin system, and the role

Expression "P-glycoprotein (P-gp) is a key component of the intestinal epithelium playing a pivotal role knockout cell lines, as well as mouse models, we confirmed the RNA sequencing findings and discovered a role

Considering this, we investigated the role of RGS20 as a potential prognostic marker in 28 different

Recently, many novel discoveries have underlined the regulatory roles of neurotransmitters in the microenvironment Here, we provide an overview of the most novel advances concerning the role of neurotransmitters in the

DVT formation is a time-dependent inflammatory process in which NETosis plays an important role.

However, the role of β2-AR in oral cancer is not well identified.

Given the important roles of extracellular pH in the progression of pulmonary fibrosis, we sought to Proton-sensing G-protein coupled receptors are activated by acidic environments, but their role in fibrosis Here, we report that the Ovarian Cancer G-Protein Coupled Receptor1 (OGR1 or GPR68) has dual roles in

γ-aminobutyric acid receptor (GABABR), a class C G protein-coupled receptor (GPCR) heterodimer, plays a crucial role