Search Results
237 items found for "Tectonic Therapeutic"
- 📰 GPCR Weekly News, July 31 to August 6, 2023
GPCR Symposium on 'GPCRs as Therapeutic Modalities' is set for September 22nd. Additional Chf 2.7 Million From Indivior In Extended Substance Use Disorder Research Collaboration Addex Therapeutics
- Targeted Therapies to Reduce Side Effects in Modern Drug Development
years to uncover the mechanisms of disease before they can even dare to contemplate the development of therapeutic
- A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
These findings indicate the potential of inhibiting MC4R homodimerization as a therapeutic target to
- To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from...
These insights will facilitate further development of therapeutic agents targeting the DOR.Communicated
- Sosei Heptares Confirms Senior Leadership Changes to Drive the Company Through the Next Stage ...
Matt Barnes appointed President of Heptares Therapeutics Ltd., and Head of UK R&D Tokyo, Japan and
- 📰 GPCR Weekly News, November 13 to 19, 2023
identification of potential agonists of FFAR4 for type 2 diabetes mellitus therapy Industry News OMass Therapeutics (ANDA) Litigation PostEra Announces a Research Collaboration with Amgen to Discover Small Molecule Therapeutics
- Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
It is a therapeutic target because it plays a role in thermogenesis, lipolysis, and bladder relaxation
- Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic di
consequently activated signaling pathways, and also may shed light on the development of more effective new therapeutics
- In vitro assays for the functional characterization of (psychedelic) substances at the serotonin...
their appearance on the (illicit) drug market, e.g. as new psychoactive substances, their potential therapeutic
- 📰 GPCR Weekly News, February 27 to March 5, 2023
Industry News Design Pharmaceuticals has a new website Confo Therapeutics Announces Global Licensing Antiverse raises €2.8M for its computational antibody drug discovery platform Antiverse identifies therapeutic
- Combined docking and machine learning identify key molecular determinants of ligand pharmacological
September 2022 "G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases
- Precise druggability of the PTH type 1 receptor
PTHR signaling that could be extended to GPCRs to expedite discoveries of small molecules as novel therapeutic
- G protein-coupled receptors that influence lifespan of human and animal models
substantial participation in a wide variety of processes of human pathophysiology and are one of the main therapeutic
- Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice
PTH-related protein (PTHrP) ligands and analogues for their pharmacologic activities and potential therapeutic
- Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
kinetic studies "G protein-coupled receptors (GPCRs) are an important receptor superfamily and common therapeutic
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
theoretically offer several advantages compared to orthosteric ligands when considered as potential therapeutic other GPCR-regulated systems such as free fatty acid receptors (FFARs), now regarded as targets for therapeutic
- Twist Bioscience Launches Revelar Biotherapeutics to Develop and Commercialize Novel COVID-19...
Bioscience Launches Revelar Biotherapeutics to Develop and Commercialize Novel COVID-19 and Other Antibody Therapeutics
- Crinetics Pharmaceuticals announced the formation of an independently operated new company...
stage pharmaceutical company focused on the discovery, development, and commercialization of novel therapeutics
- Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
2022 "The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an important therapeutic
- Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation..
Our results suggest that strategies to selectively target OGR1 expression may represent a novel therapeutic
- HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural ...
Overall, our work reveals insight into PI3Kγ regulation and identifies sites that may be exploited for therapeutic
- TLR4 biased small molecule modulators
Biased pharmacological modulators provide potential therapeutic benefits, including greater pharmacodynamic
- G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease..
discrete and separable effects and provide proof of concept for the development of safer GPCR-targeting therapeutics
- Differences across sexes on head-twitch behavior and 5-HT2A receptor signaling in C57BL/6J mice
2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), is receiving renewed attention for their potential therapeutic
- PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
Pc(4-4) may become a promising candidate for future therapeutic cancer treatment."
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the...
Our results suggest that GPR15/GPR15L have a pathogenic role in RA and their antagonizing could be a therapeutic
- Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to...
regulating the PI3K/AKT/GSK-3β and MEK/ERK pathways in amygdalae of male mice, implicating a potential, therapeutic
- High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...
particularly aggressive and heterogeneous disease with few effective targeted therapies and precision therapeutic