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362 items found for "Vivian G Oehler"
- 📰 GPCR Buzz: August 5-11, 2024 | Top Highlights from DrGPCR University!
concentrations induces toxicity across multiple generations associated with inhibition in germline G human induced pluripotent stem cell-derived nociceptive-like neurons Methods & Updates in GPCR Research G protein-coupled receptor (GPCR) pharmacogenomics Visualization of endogenous G proteins on endosomes
- Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery
Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery G-protein-coupled receptors and biased signalling, using PAFR as a model, showing that stabilization of PAFR oligomers promotes G GPCRs dimers exist in a transient state however they are still able to be activated and interact with G GPCR drugs efficacy usually depends on a pathway (G protein or β-arrestin), whereas side effects are
- 📰 GPCR Weekly News, January 29 to February 4, 2024
non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G selective GPCR signaling GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway Non-canonical G Industry News Launch of GIO Therapeutics, founded by Cumulus Oncology, to develop therapeutics targeting G and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein
- GPCR Updates: Celebrating Breakthroughs, New Course Launches Soon, and Exclusive Discounts! | Aug 26 - Sep 1, 2024
Małgorzata Kogut-Günthel , Antonella Di Pizio , et al. for their research on The path to the G protein-coupled GPCR Event Spotlight Discovery on Target’s 19th Annual GPCR-Based Drug Discovery Targeting G Protein-Coupled by minimal RGS domains disrupts circuit functionality and circuit formation Reviews, GPCRs, and more G Protein-Coupled Receptors in Skin Aging The path to the G protein-coupled receptor structural landscape
- Delineation of GPR15 receptor-mediated Gα protein signaling profile in recombinant mammalian cell
September 2022 "The GPR15 receptor is a G protein-coupled receptor (GPCR), which is activated by an endogenous pharmacological tool compounds to delineate the GPR15 receptor-mediated Gα protein signalling using a G
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
The C5aR1 is a classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that tailors immune cell activity potentially through β-arrestins rather than G-proteins.
- Structural landscape of the Chemokine Receptor system
Chemokine receptors (CKRs) belong to a subfamily of G-protein-coupled receptors (GPCRs) and play a crucial CKRs can be classified into typical CKRs, atypical CKRs (ACKRs) which lack G-protein signaling, and viral instead TM7 and the intracellular helix 8 move outward from the receptor core to make room for the G-protein It has been demonstrated that the shorter truncation variant, CCL15L, exhibits bias toward G-protein signaling or not, although the precise molecular signature responsible for G-protein activation by CCR1
- 📰 GPCR Weekly News, March 25 to March 31, 2024
TRPM5 activation depends on a synergistic effect of calcium and PKC phosphorylation After wounding, a G-protein receptor associates with CXCR4 multimers in human cancer cells [Inhibitory effect of downregulating G salt tolerance, and chromatographic performance Fluorine-19 labeling of the tryptophan residues in the G and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein
- Decoding β-Arrestins: from Structure to function
intracellular cavity (Kang, Y. et al. 2015, Chen, Q. et al. 2021), that allow interaction with trimeric G diverse responses based on cell-specific G protein expression. Apart from G proteins, GPCRs engage other effectors for signaling modulation. Originally recognized for inhibiting G protein signaling, they also influence specific pathways such G. 2021).
- Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin ...
We previously demonstrated that the G protein-coupled receptor (GPCR) arginine vasopressin receptor type1A CRPC cell proliferation through cAMP/protein kinase A signaling, consistent with AVPR2 coupling to the G
- RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα
Here, we sought to investigate the role of Regulator of G Protein Signaling 7 (RGS7) in hyperlipidemia-dependent
- 📰 GPCR Weekly News, May 1 to 7, 2023
Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders. Structural and Molecular Insights into GPCR Function Structural insight into an anti-BRIL Fab as a G-protein-coupled
- Aβ peptides stabilize GPCRs in inactive form and trigger inverse agonism in Alzheimer's disease
August 2022 "Several G-protein coupled receptors (GPCR) are upregulated in Alzheimer's Disease (AD),
- Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to...
Upregulated PSD95 Expression, and Abnormal Activation of the PI3K/AKT/GSK-3β and MEK/ERK Pathways "Adhesion G protein-coupled receptor A1 (ADGRA1) belongs to the G protein-coupled receptor (GPCR) family, and its
- 📰 GPCR Weekly News, January 16 to 22, 2023
Structural and Molecular Insights into GPCR Function The role of G protein conformation in receptor-G Deadline February 12, 2023 Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology
- Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent ...
Recently, it has been shown that murine Latrophilins mediate classical G-protein signals to drive synaptogenesis Latrophilins are essential for neuronal physiology, possibly complementing canonical functions via G
- Diversity and specificity in location-based signaling outputs of neuronal GPCRs
August 2022 "The common mechanisms by which members of the G protein-coupled receptor (GPCR) family respond
- 📰 GPCR Weekly News, July 24 to July 30, 2023
Adhesion GPCRs Dual role of the adhesion G-protein coupled receptor ADRGE5/CD97 in glioblastoma invasion G protein-coupled receptor-mediated membrane targeting of PLCγ2 is essential for neutrophil chemotaxis GPCRs in Oncology and Immunology Interplay between G protein-coupled receptors and nanotechnology.
- New role of β-arrestins in MOR signaling
Opioid receptors belong to class A of G protein-coupled receptors or GPCRs and signaled mainly through that have addressed the differences in the mechanisms of transduction triggered by MOR, reporting that G-protein This report highlights a mechanism of β-arrestin pathway activation dependent on G protein activation These findings highlight how G proteins and β-arrestins are involved in driving intracellular signaling
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
composition, organization, and physical properties might impact ligand binding, receptor activation, G internalization via interaction with the adaptor protein 2 (AP2) and clathrin heavy chain mediating G Classical and new roles of b-arrestins in the regulation of G-protein-coupled receptors. Nat. Rev. Diversity and specificity in the regulated endocytic membrane trafficking of G-protein-coupled receptors
- 📰 GPCR Weekly News, August 28 to September 3, 2023
Cardiomyocytes Dopamine Receptor D1 Is Exempt from Transforming Growth Factor β-Mediated Antifibrotic G A case for (mutant) G protein-coupled receptors Reviews, GPCRs, and more RGS2 and female common diseases women's health β-Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives COVID-19, G
- 📰 GPCR Weekly News, April 3 to 9, 2023
GPCRs in Cardiology, Endocrinology, and Taste Novel roles for G protein-coupled receptor kinases in cardiac GPCRs in Neuroscience G protein-coupled receptors (GPCRs) as Potential Therapeutics for Psychiatric Disorders Reviews, GPCRs, and more Heterotrimeric G proteins regulate planarian regeneration and behavior.
- 📰 GPCR Weekly News, March 6 to 12, 2023
GPCR Binders, Drugs, and more Autoantibodies targeting G protein-coupled receptors: An evolving history GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery.
- Residency time of agonists does not affect the stability of GPCR-arrestin complexes
September 2022 " Background and purpose: The interaction of arrestins with G-protein coupled receptors
- Ono Enters into Collaboration Agreement with Domain Therapeutics and Université de Montréal for ...
”) and Université de Montréal (Québec, Canada; “UdM”), to discover novel small molecules targeting G-Protein
- Confo Therapeutics receives €1.7 million VLAIO grant for further research on GPCR modulators for ...
The grant should help expand Confo Therapeutic ’s research on G protein-coupled receptor (GPCR) drug
- 📰 GPCR Weekly News
Research Middle-Down Mass Spectrometry Reveals Activity-Modifying Phosphorylation Barcode in a Class C G Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology.
- Tectonic Therapeutic Strengthens Leadership Team
pre-clinical stage biotechnology company transforming the discovery of novel GPCR-targeted therapies (G-Protein