October 2022 "Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological

Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

Barry Rubenstein as Senior Vice President, People and Culture and Washington Alves as Vice President, Biologics

August 2022 "Psychedelic research across different disciplines and biological levels is growing at a

for a number of inflammatory diseases including atherosclerosis, scleroderma, multiple sclerosis and cancer and efficiently advance a diversified portfolio of GPCR-targeted drug candidates for the treatment of cancer methodology for engineering small protein GPCR ligands Paolini-Bertrand, M. et al. (2018) The Journal of Biological

Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

cell-surface proteins with large extracellular regions that bind to multiple ligands to regulate key biological

The careful structural modifications during the lead optimization phase led to a compound with high biological

However, how these states impact GPCRs biological function and therapeutic targeting remains incompletely

Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

technologies that stabilize G protein–coupled receptors (GPCRs) to enable the discovery of agonistic biologics

Antibody developers are increasingly utilising antibody libraries to derive high-quality, drug-like biologics

June 2 - 4, 2024 | Chemotactic Cytokines GPCR Jobs NEW Researcher / Senior Researcher in Structural Biology

It is classified into two types: Sigma-1 (S1R) and Sigma-2 (S2R) based on their biological functions.

We envision that our results could have potential implications in structural biological advancements

as well as practical aspect of these topics, the platform addresses students and researchers with a biological

Therefore, this study aimed to conduct prospective virtual screening and confirm the biological activity

Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

C5a-C5aR2 interaction compared to C5a-C5aR1, which will surely help in elaborating the currently debated biological

Expression is directed by the endogenous mouse promoter and hence occurs in all biologically relevant

particular show a progressive tendency to aggregate and precipitate in aqueous solution outside of their biological

enrichment analysis indicated that the mechanism of KXS in treating depression was involved in the biological

Rapid flip-flop of phospholipids across the two leaflets of biological membranes is crucial for many

., BRET biosensors to study GPCR biology, pharmacology, and signal transduction. 

Neuropeptides and their specific receptors (primarily G protein-coupled receptors, GPCRs) regulate multiple biological

Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

vitro pharmacology - Crinetics Pharmaceuticals In vivo Antibody Discovery Research Scientist In Vitro Biologist