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268 items found for "drug combination"
- Domain Therapeutics Raises $42m Series A Financing
Therapeutics , a biopharmaceutical company specializing in the research and development of innovative drugs
- GPCR Therapeutics Expands Scientific Advisory Board
venture-backed clinical stage international biopharmaceutical company with an innovative approach to drug
- Trevena Announces Advancement of TRV045 Into Clinical Development for Diabetic Neuropathic Pain
Food and Drug Administration (FDA) that the study may proceed.
- Single-molecule counting applied to the study of GPCR oligomerization
signaling proteins that participate in many vital physiological functions making them a popular target for drug
- Molecular basis for ligand modulation of the cannabinoid CB 1 receptor
A variety of ligands for CB1 receptors have been developed as promising drug candidates for the treatment
- Arginine 125 Is an Essential Residue for the Function of MRAP2
helps in elucidating the metabolic pathways involved in metabolic dysfunction and in developing new drugs
- Adenosine receptor signalling in Alzheimer's disease
into some novel strategies, including allosterism and the targeting of oligomers, which may increase drug
- Search for safer pain relief advances with new engineered compounds
in Florida have created a collection of new pain-relieving compounds that, like morphine and other drugs
- Adenosine receptor signalling in Alzheimer's disease
into some novel strategies, including allosterism and the targeting of oligomers, which may increase drug
- GPR110, a receptor for synaptamide, expressed in osteoclasts negatively regulates osteoclastogenesis
Our study suggested that ligands of GPR110, such as synaptamide, might be a useful drug for osteoporotic
- Addex Reports 2022 Half Year and Second Quarter Financial Results and Provides Corporate Update
SIX and Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug
- 📰 GPCR Weekly News, March 18 to 24, 2024
in GPCR signaling G protein-coupled receptor-mediated autophagy in health and disease GPCR Binders, Drugs 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug
- Addex Therapeutics Completes Patient Enrollment For Dipraglurant Blepharospasm Phase 2 Clinical ...
ADXN, Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug
- Orion Announces The Rapid Lead Optimization Of Ob-004 - A Ccr2 Antagonist
stage company unlocking the therapeutic potential of G Protein-Coupled Receptors (GPCRs) with a novel drug
- Activation of the human chemokine receptor CX3CR1 regulated by cholesterol
However, the drug development of CX3CR1 is hampered partially by the lack of structural information.
- Molecular insights into regulation of constitutive activity by RNA editing 5HT2C serotonin receptor
5HT2C-transducer-coupled structures of three representative isoforms (INI, VGV, and VSV) with the selective drug
- 📰 GPCR Weekly News, June 3 to June 9, 2024
mediator for methionine to stimulate milk synthesis in mouse mammary epithelial cells GPCR Binders, Drugs ADCS) Septerna Presents Preclinical Data at ENDO 2024 Highlighting Therapeutic Potential of its GPCR Drug
- New role of β-arrestins in MOR signaling
According with the National Institute on Drug Abuse (NIDA) nearly 92, 000 Americans died from drug-involved Opioids are analgesic drugs consumed non-medically for euphoric feelings and medically for pain relief
- Addex Expands Pipeline With Selective M4 Positive Allosteric Modulator Program For The Treatment ...
ADXN and Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug
- Hear the sounds: the role of G protein-coupled receptors in the cochlea
And A1, A2A, and CB2 activation by agonists has protective functions on noise- or drug-induced hearing
- Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
expressed in mast cells, macrophages, and in cardiovascular tissue, linking them to pseudo-allergic drug mediator and supports the notion that IL-6 can be used as a marker for MRGPRD activation in an in vitro drug
- Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand...
To understand the basis of the ligand preferences of the receptors and to assist structure-based drug
- 📰 GPCR Weekly News, April 1 to 7, 2024
Intracellular pocket conformations determine signaling through the μ opioid receptor GPCR Binders, Drugs , and more Predicting associations between drugs and G protein-coupled receptors using a multi-graph
- TM5-TM6: structural switches that modulate the coupling of serotonin receptors to Gs or Gi
pocket is of great importance in GPCRs field as it supports the development of alternatives to improve drug residues of both G protein families, suggesting that receptors that activate both Gs and Gi/o do so by combining
- Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of...
transmembrane sites for accurate characterization, binding-affinity calculations, and lead optimization in drug
- Nanobodies as Probes and Modulators of Cardiovascular G Protein-Coupled Receptors
cardiovascular medicine due to the critical physiological roles of these receptors and their prominence as drug
- 📰 GPCR Weekly News, June 19 to 25, 2023
GPCR Binders, Drugs, and more Molecular Characterization of Two Wamide Neuropeptide Signaling Systems Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24
- G-protein-coupled receptors as therapeutic targets for glioblastoma
receptor-4 (MC4R), adhesion, lysophosphatidic acid (LPA) and smoothened (Smo) receptors to initiate new drug-screening