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254 items found for "drug repurposing"
- Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis
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- Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling
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- NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
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- The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 replication
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- Signaling by Neutrophil G Protein-Coupled Receptors that Regulate the Release of Superoxide Anions
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- Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans
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- Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors
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- Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer
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- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
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- Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation
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- Metabolic crosstalk: Extracellular ATP and the tumor microenvironment in cancer progression and therapy
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- From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction
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- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
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- Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration
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- Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation
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- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
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- Delivery of US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes
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- Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer
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- The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor
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- Evolutionary diversity of CXCL16-CXCR6: Convergent substitutions and recurrent gene loss in sauropsids
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- CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation
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- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium
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- TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling
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- Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes
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- RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment
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- Transcriptomic analysis of human cytomegalovirus to survey the indirect effects on renal transplant recipients
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- Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway
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- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
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