agonism at the GLP-1R represents a promising strategy for optimizing therapeutic outcomes in metabolic diseases

Endocrinology, and Taste Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease

A case for (mutant) G protein-coupled receptors Reviews, GPCRs, and more RGS2 and female common diseases

GPCRs in Neuroscience Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson's disease

G-protein coupled receptor-mediated vasocontraction in rat coronary arteries GPCRs involved in metabolic diseases

Collectively, these findings reveal a unique hydrogen-bonding network located on intracellular loop 2

major rearrangement of the HR seems implausible due to the tight arrangement and fixation by disulfide bonds

more The multifaceted functions of β-arrestins and their therapeutic potential in neurodegenerative diseases

midgut development in Drosophila Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases

Adhesion GPCRs Downstream signaling of the disease associated mutations on GPR56/ADGRG1.

screening of potential inhibitors of GPR52 using docking and biased sampling method for Huntington's disease

and design of 5-HT6 antagonists through assessment of ANN-QSAR models in the context of Alzheimer's disease

Financial Results Novartis Automates New Radioligand Therapy Production Plant Novartis’ Lutathera reduces disease

grandiflora against Candida auris FKBP12 Development and therapeutic perspectives of CXCR4 antagonists for disease

and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases

optogenetically functionalized Drosophila dopamine receptors Targeting CB2R in astrocytes for Parkinson's disease

GPCR-related genes analysis Reviews, GPCRs, and more GPR56, an Adhesion GPCR with Multiple Roles in Human Diseases

GPCR-Mediated Natural Products and Compounds: Potential Therapeutic Targets for the Treatment of Neurological Disease

A Perspective on Class C GPCR Based Genetically Encoded Biosensors Emergence of lumpy skin disease virus

Endocrinology, and Taste The role of P2Y6 receptor in the pathogenesis of cardiovascular and inflammatory diseases

Ghrelin receptor signaling in health and disease: a biased view.

We show that besides classical hydrogen bonds, weak polar interactions such as O-HC, O-Br, and long-range

The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards

epithelial cells proliferation via activation by β-ionone which initiates prostate cancer cell cycle arrest (Jones to the diversity of the OR family it will be critical to select potential targets to modulate in a disease

the promise of unveiling novel insights into cellular signaling and its implications for health and disease

will likely bring together some of the hottest adhesion GPCR research going on right now and set the tone Of course, there is the famous parade popularized by the James Bond movie Spectre.

domain through an auto-catalysis process generating two peptides that are held together by non-covalent bonds

Schiff base, and prevents protein degradation, potentially offering therapeutic benefits for retinal diseases6