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180 items found for "immune system"
- 📰 GPCR Weekly News, March 25 to March 31, 2024
Therapeutics to Present Latest Data on DT-9045, a First-in-class Negative Allosteric Modulator of PAR2 for Immuno-oncology
- Decoding β-Arrestins: from Structure to function
Fine-tuned systems of protein expression regulate various processes, and their imbalance is linked to
- Ode to GPCRs
Richard Kandel, Arvid Carlsson, and Paul Greengard for research on signal transduction in the nervous system Dopamine exerts its action in the human nervous system via dopamine receptors and human trace amine-associated
- Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
Gupte et al. utilized a systematic protein affinity strength modulation (SPASM) technique to show that
- 📰 GPCR Weekly News, June 3 to June 9, 2024
protein-biased allosteric modulator of cannabinoid receptor CB1 GPCR function in autophagy control: a systematic
- Adhesion GPCR Consortium Newsletter - May 2024
PMID 38421639 Systematic assessment of the tethered agonist-dependent activities of all 33 aGPCRs in
- 📰 GPCR Weekly News, April 22 to 28, 2024
Parenting behaviors in mice: Olfactory mechanisms and features in models of autism spectrum disorders Systematic
- 📰 GPCR Weekly News, January 15 to 21, 2024
Production Of Highly Potent Gq-Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont Systematic
- Allosteric modulation of GPCRs: From structural insights to in silico drug discovery
In this review, we provide a systematic analysis of the currently available GPCR structures in complex
- Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept
Systematic modification of 1 was performed to produce compounds with improved potency and ADME properties
- Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled ...
To test this possibility, we systematically aggregated somatic cancer mutations across class A GPCRs
- Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas ...
Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas: a systematic Moreover, through systematic survival analysis on OR genes, OR51E1 (mouse Olfr558) was identified as Based on this systematic analysis and review of the genomic and transcriptomic profiles of ORs in glioma