Genetically encoded fluorescent biosensors allow intracellular signaling dynamics to be tracked in live cells

S1P5 is predominantly expressed in nervous and immune systems, regulating the egress of natural killer cells from lymph nodes and playing a role in immune and neurodegenerative disorders, as well as carcinogenesis

September 2022 "Research on cancer therapies focuses on processes such as angiogenesis, cell signaling

Submit a 1-minute abstract video and tell us more about your project using this form. Intracellular calcium ion transients evoked by cell poking independently of released autocrine ATP in Madin-Darby canine kidney cells.

This ORF was also cloned and expressed in HEK-293 cells.

interaction were conducted, confirming decreased homodimerization capacities of chimeric receptors in HEK293 cells

transduce signals across the plasma membrane and orchestrate a multitude of physiological processes within cells

: Implications for metabolic regulation G protein-coupled receptors (GPCRs) are a large family of cell

previously uncharacterized variants, that exhibit diminished plasma membrane expression in HEK293T cells

selective small molecules with strong negative allosteric and biased properties for PTHR signaling in cell

first synthesized a fluorescent ligand enabling equilibrium and kinetic binding studies via NanoBRET as well Applying this molecular tool in a membrane-based setup and in living cells, we discovered a 4-aminopyrimidine

her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in MCF7 breast cancer cells kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells

process of de-orphanizing, is of great importance in order to better understanding human physiology as well GPR84 is a Gi‐coupled class A GPCR mainly expressed in immune cells and microglia in the brain (Wojciechowicz Regarding the first question, GPR84 overexpression in immune cells in a range of pro‐inflammatory disorders in respect to tool compounds to study the function of this receptor towards clinical validation, as well In addition, several GPR84 ligands have been described as well as GPR84 knockout mice.

endoplasmic reticulum stress, dysregulated immune tolerance, vascular inflammation and endothelial cell

Last month a very detailed paper analyzed the molecular mechanisms of the aGPCRs self-activation as well self-activation of aGPCRs, some of which differ from those of GPCRs belonging other families, and I will tell Through cell-based assays and Cryo-EM of high quality, it was possible to know that ADGRL3 can activate Araç, D., et al., A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis Molecular cell, 82(22), 4340–4352.e6.

FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Scientist - Antibody Engineering NEW Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based

regulates the expression and alternative splicing of genes associated with aphasia-related diseases in PC12 cells Scientist Senior Research Associate/Associate Scientist, Protein Science Post-Doctoral Fellow—Pharmacology/Cell

classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that tailors immune cell

wide array of physiological and disease functions, yet knowledge of their role in colon cancer stem cell A truncated form of β-catenin, ∆N133β-catenin, devoid of lysine, as well as serine/threonine residues

structural conservation across distant species Industry News Avantor's (AVTR) New Offerings to Aid Cell and Gene Therapy Suite Avantor® Expands Cellular Science Offerings with Multispan Cell Engineering and

Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell-derived Updates in GPCR Research Alared: Solvatochromic and Fluorogenic Red Amino Acid for Ratiometric Live-cell

discuss the physiological significance of GPCR scramblase activity and the modes of its regulation in cells

recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor density in cell

depression was involved in the biological process of GPCR signal transduction, hormone metabolism and nerve cell

of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells blockers   GPCR Events, Meetings, and Webinars September 18, 2024 | FREE Webinar - The value of GPCR cell-based

13-coupled designer GPCR GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells Senior Research Associate/Associate Scientist, Protein Science NEW Post-Doctoral Fellow—Pharmacology/Cell

evolution of GPCRs, and expand our knowledge of the cladoceran GPCR gene repertories which in part, mediate cell

GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for cancer therapy 15, 2023) GPCRs in drug discovery: challenges & solutions (June 19 - 23, 2023) Training School on “Cell-based