Search Results

During pregnancy, the mammary gland (MG) undergoes remodeling, which involves alveolar differentiation of mammary epithelial cells (MECs), which is essential for breast milk production and secretion. by assessing changes in cellular viability, lipid accumulation, and gene and protein expression of major milk protein and lipid synthesizing markers. using the HC11 cells as a model. that THC and CBD will negatively impact the synthesis of milk proteins and lipids, as well as lipid markers

arrhythmias and disrupts the fine-tuning of Gi/o signaling "Aims: Cardiac contractility, essential to maintaining Whether RGS2 and 5 redundantly control G protein signaling to maintain cardiovascular homeostasis is

system highlights the potential roles of phosphodiesterase 6 (PDE6) and guanylate cyclases (GCs) in maintaining

fundamental physiological functions, and dysregulation of dopaminergic transmission is associated with major endogenous dopaminergic circuits have limited specificity, reversibility, resolution, or require genetic manipulation We demonstrate that azodopa activates D1-like receptors in vitro in a light-dependent manner.

Although many cardiovascular GPCRs have been extensively studied as model receptors for decades, new We also discuss how advancing technologies to discover nanobodies with tailored specificities may expand

October 2022 "Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and bind the receptor through both hydrophobic and polar interaction, while Gi/G12/G13 engage receptor mainly

October 2022 "CXCR1 and CXCR2 chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8),

protein-coupled receptors (GPCRs) play critical roles in human physiology and are one of the prime targets for marketed

Fluorescent probes allowed semi-quantitative receptor mapping in living cells and validated the specific

cavities at the receptor-lipid interface represent an uncharacteristic binding location that raises many

Despite a better understanding of the disease, the current mainstay of treatment cannot modify pathogenesis provide insights into some novel strategies, including allosterism and the targeting of oligomers, which may

endocytosis in HEK293 and Huh-7-Lunet cells after activation by glucagon within 5 min and transit via EEA1-marked

neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection "Healthy skin maintains study demonstrated the importance of epithelial-neutrophil signaling via the defensin-Mrgpra2 axis in maintaining

time of peak hypersensitivity implicate potential contributions of mitogen-activated protein kinase (MAPK development of 7α,25-OHC/GPR183-induced mechano-allodynia was associated with significant activation of MAPKs mechanistic insight into how GPR183 signaling in the spinal cord produces hypersensitivity through MAPK We found that 7α,25-OHC-induced allodynia is dependent on MAPK and NF-κB signaling pathways and results

The molecular mechanisms N. meningitidis employ to manipulate the immune system, translocate the mucosal During this process, we also characterized two mammalian N-acyl amides derived from the bovine medium Both groups of metabolites suppress anti-inflammatory interleukin-10 signaling in human macrophage cell

Despite the drastic effects of the MC3R deficiency in humans and other mammals, its cellular mechanisms In this review paper, we aimed to point out the importance of the MC3R regulations in three main concepts

We discuss how such events may be distinct depending on where the GPCRs and their associated signaling machinery are localized in these cells with an emphasis on nuclear membrane-localized receptors.

pharmacology is derived from rodent models, but most of this preclinical research has only focused on male of DOI on head-twitch behavior (HTR) - a mouse behavioral proxy of human psychedelic potential - in male DOI elicited more HTR in female as compared to male C57BL/6J mice, a sex-specific exacerbated behavior Volinanserin (or M100907) - a 5-HT2AR antagonist - fully prevented DOI-induced HTR in male and female plasma concentrations of DOI were lower 30 and 60 min after drug administration in female as compared to male

which block the effects of angiotensin II (AngII) and aldosterone on the failing heart, are part of the mainstay

Activation of PAR2 by GB83 markedly elicited an increase in intracellular calcium levels and phosphorylation of MAPKs, but in a delayed and sustained manner compared to the rapid and transient signals induced of the localization and function of PAR2 was significantly delayed after stimulation by GB83, which may

The mGlu5 receptor is activated by the main excitatory neurotransmitter of the nervous central system

is better than AlphaFold's 5.53 Å and RoseTTAFold's 6.28 Å, probably since Modeller already included many

protein-coupled receptors in placental development and preeclampsia "Preeclampsia, a clinical syndrome mainly characterized by hypertension and proteinuria, with a worldwide incidence of 3–8% and high maternal mortality, is a risk factor highly associated with maternal and offspring cardiovascular disease. The pathogenesis of preeclampsia include poor placentation, uteroplacental malperfusion, oxidative stress

Recent evidence indicates that GPR15 may be associated with modulation of the chronic inflammatory response Statistical analysis included Kruskal-Wallis test, T-test, or Mann-Whitney U test, according to data

(PAR), a subgroup of GPCRs, form a family of four members (PAR1-4) centrally involved in epithelial malignancies It effectively attenuates PAR2&4-Akt/PKB associations; PAR4 instigated Matrigel invasion and migration We propose that Pc(4-4) may serve as a powerful drug not only toward PAR-expressing tumors but also for Pc(4-4) may become a promising candidate for future therapeutic cancer treatment."

techniques enable a precise determination of the intracellular abundance and stoichiometry of proteins and macromolecular G-protein-coupled receptors-an expansive class of transmembrane signaling proteins that participate in many vital physiological functions making them a popular target for drug development.

increasing prevalence of obesity and type 2 diabetes (T2DM) is provoking an important socioeconomic burden mainly Moreover, the main investigations into animal models and ongoing clinical trials using these unimolecular

neuroactive ligand-receptor interaction pathway, serotonergic synapse pathway, PI3K-Akt signaling pathway and MAPK ligand -receptor interaction pathway, serotonergic synapse pathway, PI3K-Akt signaling pathway and MAPK