GPCR Podcast << Back to podcast list Dr. Terry Hébert About this episode Dr. Instead, he ended up getting interested in membrane protein as he followed the biology of a bacterial Today he and his team are working on understanding receptor signaling in specialized cellular environments to gain a better grasp of receptor function in pathophysiological settings with a special interest in His favorite GPCR is the angiotensin 1 receptor, especially for its ability to activate a large variety

schedule Biased agonism at the GLP-1 receptor: from structure to animal models of disease Date & Time Senior Principal Research Fellow and Director, ARC Centre for Cryo-electron Microscopy of Membrane Proteins He is a leader in the study of GPCRs. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by

A3 Adenosine Receptors in Cancer Cell Lines Published date September 7, 2023 Abstract "A3 adenosine receptor is an interesting target that showed controversial roles in cancer. [1,2,4]triazolo[1,5-c]pyrimidines has been carried out, obtaining potent and selective A3 adenosine receptor and A1 and A2A adenosine receptors. GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to The NMDA receptor is a subtype of glutamate neurotransmitter receptor that regulates the formation and GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

< GPCR News < GPCRs in Oncology and Immunology Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration Published date February 1 , 2023 Abstract "C-X-C chemokine receptor 4 (CXCR4) is widely overexpressed in various types of cancer The roles of histamine and histamine receptor H1 (HRH1) in cancer pathogenesis remain controversial. & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

the host-pathogen protein-protein interactions in Penaeus vannamei and Vibrio parahaemolyticus Published The P. vannamei-V. parahaemolyticus protein-protein interaction of Complex 1 (Ferritin-HrpE/YscL family type III secretion apparatus protein), Complex 2 (Protein kinase domain-containing protein-Chemotaxis CheY protein), and Complex 3 (GPCR-Chemotaxis CheY protein) was found to interact with -4319.76, -5271.39 & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

GPCR Podcast << Back to podcast list A Brief History of allosteric modulation with Dr. his mentors and significant discoveries related to allosteric receptors. Allosteric Modulation and Drug Discovery Yamina and Arthur delved into the complexities of protein-protein They discussed various modulatory elements, such as RAMPs, G proteins, and GRKs, with Arthur recounting his initial collaboration with Patrick Sexton on RAMPs and amylin receptors.

GBP1 expression through GPCR receptor Mthl10 Published date January 29, 2024 Abstract "Growth-blocking Moreover, the GBP2-induced response was silenced by pre-treatment with dsRNA targeting the GBP receptor News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs

GPCR Podcast << Back to podcast list Dr. Kathryn E Livingston About Dr. Kathryn E Livingston Dr. Product Manager at Gator Bio , a biotechnology company providing solutions to researchers studying protein-protein John Traynor , Kathryn worked to develop and understand first-in-class allosteric modulators of opioid receptors There she researched the beta-2 adrenergic receptor and developed assays to investigate real-time activity GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand

Application of this knowledge to determine the mechanism of action of new GPCR ligands. The required elements of a comprehensive and effective GPCR Discovery. Modules: Lecture 1: GPCR Project Initiation and Design for Discovery of New Molecules. Lecture 3: Agonists and Efficacy: A New World of GPCR Efficacies / Biased Signaling. My interests are in receptor theory, pharmacology applied to drug discovery and allosteric protein function

GPCR Podcast << Back to podcast list Dr. Antony A. Boucard Jr About Dr. Antony A. Boucard Jr. Dr. It is then that his interest bloomed for the study of GPCRs while joining the group of Dr. interest in the cardiovascular system by investigating the structure of the Angiotensin and Urotensin receptors Alfred Gilman , Nobel Laureate for his discovery of G proteins, Dr. pharmacology of latrophilins brings about a great deal of challenges given that they are highly polymorphic proteins

GPCR Podcast << Back to podcast list Gáspár Pándy-Szekeres About Gáspár Pándy-Szekeres " After a BSc My initial focus was on creating an automated chimeric homology modeling pipeline for GPCRs and since have branched out to multiple areas of GPCR research such as sequence alignments, generic numbering systems, structure data, G protein and arrestin coupling and more. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs

GPCR Podcast << Back to podcast list Dr. Lukas Grätz About Dr. My initial focus was on creating an automated chimeric homology modeling pipeline for GPCRs and since have branched out to multiple areas of GPCR research such as sequence alignments, generic numbering systems, structure data, G protein and arrestin coupling and more. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs

After 2-24 h, brains were collected for the analysis of gene expression by RT-PCR or protein expression and then with LPS (100 ng/ml) followed by 10 nM synaptamide for 2 h for gene expression and 12 h for protein GPR110 ligand decreased the mRNA and/or protein expression of these cytokines and Iba-1 in the WT but PDE4B expression at both mRNA and protein level in the brain increased after ethanol and LPS treatment papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more

GPCR Newsletter We want to bring you closer to what's happening in the GPCR world and yet want to avoid up with the idea of a monthly newsletter in which we've curated the major advances in understanding GPCR biology and moving closer to targeting receptors in diseases.

GPCR Ecosystem Member How can you benefit from the Dr. GPCR University? Symposia Would you like to stay up-to date on your GPCR research? Join us each month Classified News Dig into the latest GPCR news here! Find out about your favorite receptor or company today! Job listings Are you looking to hire?

< GPCR News < GPCRs in Oncology and Immunology Enterococcus-derived tyramine hijacks α2A-adrenergic receptor Here, we identify α2A-adrenergic receptor (ADRA2A) as a highly expressed GPCR in ISCs. Enterococcus , IBD , ISCs , colitis , inflammatory bowel disease , tyramine , yohimbine , α(2A)-adrenergic receptor papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology

GPCR Podcast << Back to podcast list Dr. proteins signaling by accessory proteins, such as RGS proteins and GPSM proteins. After her Ph.D., she moved to Australia and continues working on GPCRs. Her current research focuses on class B GPCRs and understanding how GPCR signaling and function is mediated Join me to learn more about Elva, class B GPCRs, and Tilly. Dr.

GPCR Podcast << Back to podcast list Dr. Nariman Balenga About Dr. and received my Ph.D. in Molecular Medicine in 2010 after studying the orphan atypical cannabinoid receptor I was fascinated by the multitude of processes that are regulated/dysregulated by GPCRs and RGS proteins A fungal serine protease allergen with GPCR-modulating features was discovered as a new biomarker and I studied the function of RGS5, calcium-sensing receptor, and an orphan adhesion GPCR, GPR64/ADGRG2 in

< Back 241204 Did you know allosteric modulators can change the GPCR G protein subtype selectivity? GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. Read more Previous Next

< Back 241024 Did you know allosteric modulators can change the GPCR G protein subtype selectivity? GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. Read more Previous Next

< Back 241022 Did you know allosteric modulators can change the GPCR G protein subtype selectivity? GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. Read more Previous Next

< Back 241022 Did you know allosteric modulators can change the GPCR G protein subtype selectivity? GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. Read more Previous Next

< Back 241203 Did you know allosteric modulators can change the GPCR G protein subtype selectivity? GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. Read more Previous Next

< Back 241205 Did you know allosteric modulators can change the GPCR G protein subtype selectivity? GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. Read more Previous Next

< Back 241031 Did you know allosteric modulators can change the GPCR G protein subtype selectivity? GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. Read more Previous Next

< Back 241029 Did you know allosteric modulators can change the GPCR G protein subtype selectivity? GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. Read more Previous Next

< Back 241015 Did you know allosteric modulators can change the GPCR G protein subtype selectivity? GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. Read more Previous Next