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264 items found for "IJzerman AP"
- Arginine 125 Is an Essential Residue for the Function of MRAP2
protein-coupled receptors, such as the prokineticin receptors, and regulates energy expenditure and appetite
- Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...
breast cancer "Quantitative systems pharmacology (QSP) modeling is an emerging mechanistic computational approach , the modularized QSP platform can be readily reproduced, expanded for new species of interest, and applied
- Multifunctional role of GPCR signaling in epithelial tube formation
gland (SG) invagination, the GPCR ligand Folded gastrulation (Fog) activates Rho1 signaling to drive apical regulate Rho kinase accumulation and myosin activation in the medioapical region of cells to control apical
- Neuropeptide S Encodes Stimulus Salience in the Paraventricular Thalamus
The PVT appears to provide stimulus salience encoding in a dose- and NPS-dependent manner.
- Delineation of GPR15 receptor-mediated Gα protein signaling profile in recombinant mammalian cell
the GPR15 receptor signals through Gi/o to inhibit cAMP accumulation, which could be blocked by the application
- GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma
2022 "Background G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
The functional relevance of C5aR2 appears to be context-dependent compared to the C5aR1, which has received
- CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via...
In vitro , SACC cell proliferation and apoptosis were evaluated using Cell Counting Kit-8 and colon formation
- Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid...
Methods Proliferation, migration and apoptosis assays were performed in ovarian cancer cells after Immunoblotting approach was used to analyze signaling involved in fentanyl’s action focusing on EGFR.
- Neurocrine Biosciences Announces Positive Phase 3 Data for KINECT-HD Study Evaluating Valbenazine...
TMC Score of 3.2 Units in Valbenazine-Treated Patients- Company Plans to Submit Supplemental New Drug Application
- Sosei Heptares Announces Antitrust Clearance of License Agreement with Neurocrine Biosciences
Agreement”) with Neurocrine Biosciences , Inc. (“ Neurocrine Biosciences ”) announced 22 November 2021, the applicable With completion of the applicable waiting period under the HSR Act, under the terms of the License Agreement
- Professor Charlotte Deane Joins Exscientia as Chief Scientist of Biologics AI
In this newly created role, she will focus on the application of artificial intelligence (AI), machine
- Learn more about Neurocrine Biosciences with their new video
It captures our values and vision for the future, our culture, and our unique approach to science.
- Novo Nordisk moves to strengthen obesity efforts
January 2022 "After securing FDA approval for Wegovy last year, Novo Nordisk is strengthening its position
- Septerna emerges with $100M to spark 'second golden age' of prolific drug target GPCR with ...
Better known as GPCR, the fruitful research space has led to more than 700 approved drugs over previous
- InterAx Biotech AG and Boehringer Ingelheim take collaborate to unlock orphan targets leveraging ...
. 💊 InterAx Biotech AG discovery platform was already successfully applied in projects with biopharmaceutical
- Ono Enters into Collaboration Agreement with Domain Therapeutics and Université de Montréal for ...
April 2022 Ono Enters into Collaboration Agreement with Domain Therapeutics and Université de Montréal for GPCR-Targeted Drug Discovery " Apr.19.2022 Ono Pharmaceutical Co., Ltd.
- Naggie and Rajagopal Elected Members of American Society for Clinical Investigation
ASCI, the Association of American Physicians (AAP), and the American Physician-Scientists Association (APSA ) on April 8, 2022
- Targeted Therapies to Reduce Side Effects in Modern Drug Development
For example, chemotherapy, a powerful standard approach to kill fast-growing cancer cells, has the drawback Modern drug development approaches include a range of techniques leveraging structural biology, immunology
- Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1
This prompted us to investigate the specificity of FAB6695 and scrutinize the apparent ACKR1 expression
- Jan Steyaert Named 2022 Jacob and Louise Gabbay Award Winner
This award recognizes the combination of Steyaert’s fundamental research and his ability to apply the
- Amgen to Acquire Chemocentryx for $4 Billion in Cash
which Amgen will acquire ChemoCentryx for $52 per share in cash, representing an enterprise value of approximately
- Addex and Indivior Extend GABAB Positive Allosteric Modulator Research Collaboration for...
As part of the amended agreement, Indivior will provide Addex with CHF 850,000 (approx.
- Effects of Small Molecule Ligands on ACKR3 Receptors
ACKR3 has been described as an atypical "biased" receptor because it does not appear to signal through The development of more selective ACKR3 ligands should allow us to better appreciate the unique roles
- A new Kunitz-type snake toxin family associated with an original mode of interaction with the...
Experimental approach: We used a bio-guided screening assay to identify novel MQs and placed them phylogenetically
- Discovery of 3(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligand
Therefore, S1R ligands possess a variety of potential clinical applications with a great interest in
- Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice
To overcome this potential uncertainty, we used a homologous recombination-based knockin (KI) approach the endogenous mouse promoter and hence occurs in all biologically relevant cells and tissues and at appropriate
- Tectonic Therapeutic Strengthens Leadership Team
Vice President, Head of Research, Peter McNamara , PhD, to Chief Scientific Officer as well as the appointments