September 2022 "G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases

PTHR signaling that could be extended to GPCRs to expedite discoveries of small molecules as novel therapeutic

substantial participation in a wide variety of processes of human pathophysiology and are one of the main therapeutic

PTH-related protein (PTHrP) ligands and analogues for their pharmacologic activities and potential therapeutic

kinetic studies "G protein-coupled receptors (GPCRs) are an important receptor superfamily and common therapeutic

theoretically offer several advantages compared to orthosteric ligands when considered as potential therapeutic other GPCR-regulated systems such as free fatty acid receptors (FFARs), now regarded as targets for therapeutic

Bioscience Launches Revelar Biotherapeutics to Develop and Commercialize Novel COVID-19 and Other Antibody Therapeutics

stage pharmaceutical company focused on the discovery, development, and commercialization of novel therapeutics

2022 "The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an important therapeutic

Our results suggest that strategies to selectively target OGR1 expression may represent a novel therapeutic

Overall, our work reveals insight into PI3Kγ regulation and identifies sites that may be exploited for therapeutic

Biased pharmacological modulators provide potential therapeutic benefits, including greater pharmacodynamic

discrete and separable effects and provide proof of concept for the development of safer GPCR-targeting therapeutics

2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), is receiving renewed attention for their potential therapeutic

Pc(4-4) may become a promising candidate for future therapeutic cancer treatment."

Our results suggest that GPR15/GPR15L have a pathogenic role in RA and their antagonizing could be a therapeutic

regulating the PI3K/AKT/GSK-3β and MEK/ERK pathways in amygdalae of male mice, implicating a potential, therapeutic

particularly aggressive and heterogeneous disease with few effective targeted therapies and precision therapeutic

and stabilizing IGF1R, and suggests that it may serve as a valuable prognostic factor and potential therapeutic

the current status of ligand development targeting LPA receptors to modulate LPA signaling and their therapeutic

The scavenging function of CKRs should be considered when evaluating the safety and therapeutic efficacy

synaptic depression in dorsolateral striatum of adult male mice Methods & Updates in GPCR Research RNA therapeutics

indicated by the fact that about 40% of all drugs currently used in clinical practice mediate their therapeutic

advancing the understanding of the effects of genetic mutations on GPCR function and provide a proof of therapeutic

cognate positions across GPCR paralogs opens a window into cancer mechanisms and potential approaches to therapeutics

challenges is crucial to fully harness AI's potential in accelerating drug discovery and optimizing therapeutic

puzzles and underscores the importance of understanding cellular processes at the molecular level for therapeutic

Hopkins, Exscientia’s founder and CEO was elected a Fellow of the Academy of Medical Sciences Structure Therapeutics