In the present work, we explored the molecular basis of cholesterol-induced thermal stability of the

Taken together, these data demonstrate that key features of the MCMV lifecycle are coordinated in diverse IMPORTANCE G protein-coupled receptors (GPCRs) act as cell surface molecular "switches" which regulate

activity Multiplexed mapping of the interactome of GPCRs with receptor activity-modifying proteins Molecular cells and its use in the G-protein-coupled receptor assays Predicting the Hallucinogenic Potential of Molecules

is of great importance in order to better understanding human physiology as well as to dissect the molecular agonist ligands (Pillaiyar et al., 2018) with biased properties which can help to better elucidate the molecular

Applying this molecular tool in a membrane-based setup and in living cells, we discovered a 4-aminopyrimidine

This review therefore elaborates on the in vitro molecular techniques that have been used the most abundantly

These sites act as molecular switches that can modulate receptor activity, providing an untapped opportunity designing and evaluating biased ligands for GPCRs is complex but essential for understanding their diverse structural and mechanistic aspects of biased GPCR signaling are crucial for designing effective drug molecules

affect the lifespan of animal and human models, and in which we put a special interest in describing the molecular

In addition, the molecular mechanisms underlying GPCR-induced post-translational signaling regulation

Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and Pharmacology GPCR Jobs HIGHLIGHT Research Associate - Professor Graeme Milligan HIGHLIGHT Postdoc in Molecular

Atomistic molecular dynamics simulations of opsin in a lipid membrane reveal conformational transitions

Thus, identifying novel molecular targets for developing HF therapeutics remains a key research focus

Molecular dynamics (MD) simulations on a 1-μs time scale and metadynamics-enhanced conformational sampling

To interrogate the molecular mechanisms underlying this interaction, we conducted a host-directed CRISPR-Cas9

Molecular docking displayed low binding energies during the intermolecular interactions of kurarinone

However, its biological function and underlying molecular mechanism in breast cancer have not been clearly

Furthermore, we show that the molecular basis for biased signaling differences between PTHrP1-36 and

to exploit other mamba venoms to enlarge the V2R-Kunitz peptide family and gain insight into the MQ1 molecular

an inhibitory role in neuroinflammation, providing an opportunity to identify potential cellular and molecular

present in a range of conformations, and the binding of a ligand, as well as interactions with signaling molecules Overall, GPCRs are intriguing molecules that deviate from typical textbook proteins. They can be compared to molecular rheostats, capable of sampling a spectrum of conformations with relatively

However, cellular assays, molecular docking and site-directed mutagenesis studies have revealed that

that fluorescently labeled Hst1 (F-Hst1) targets and activates mitochondria, presenting an important molecular

sampling simulations and free-energy calculations. 2-Iodomelatonin unbinding was investigated with steered molecular

Molecular dynamics studies revealed that NF-α1/CPE interacts with 5-HTR1E via 3 salt bridges, stabilized

., 2012), which molecular signature was recently characterized (Shroka, T. M, et al. 2023).

Principles of Pharmacology in Drug Discovery I -   Techniques for Effective Lead Optimization of Candidate Molecules Structural and Molecular Insights into GPCR Function Entropy drives the ligand recognition in G-protein-coupled

repeat-containing (LGR2) gene in Hyphantria cunea (HLGR2) was performed to examine whether it can be used in the molecular

In ascomycete fungi including yeasts, mating between cells of opposite mating type depends on the molecular