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Conformational changes between inactive and active states are facilitated by a "microswitch network" As a result of the unique active conformation, the residues in the microswitch network show non-canonical share a glutamine residue at the "toggle switch" position 6.48 and the disruption of a hydrogen-bond network

CCR2 was also shown to be resistant to degradation and most likely recycling through the trans-Golgi network

Nicola Smith, Molecular Pharmacologist, lab head, and senior lecturer at UNSW Sydney.