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Adriano Marchese , et al. for their excellent work on Receptor determinants for ß-arrestin functional specificity illustrated by dopamine D2-like and β2 adrenergic receptors Receptor determinants for ß-arrestin functional specificity regulates male reproduction in teleosts: an in vitro study in Channa punctata GPCRs in Neuroscience Neuron specific Receptor Function - A Case for the 5-HT2C Receptor Reviews, GPCRs, and more Functional consequences of spatial Activation: Mutation-Induced Alterations in Structural Dynamics Molecular determinants of neuropeptide-mediated

G-protein-coupled receptors (GPCRs) can form biologically active homodimers or heterodimers which drive specific efficacy usually depends on a pathway (G protein or β-arrestin), whereas side effects are normally mediated A more in-depth analysis of the functional specificity of transmembrane peptides will provide a better

GPCRs in Cardiology, Endocrinology, and Taste Pepducin ICL1-9-Mediated β2-Adrenergic Receptor-Dependent

business update and review its pipeline during a teleconference and webcast for investors, analysts and media

coupling, since the change of amino acids in positions close to this position favored signaling toward a specific Araç, D., et al., A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

PolySia has been described for CCR7 where it specifically affects the recognition of CCL21 but not CCL19 sphingosine-1-phosphate receptor 1 (S1PR1) also carry tyrosine sulfation sites in their N-termini that mediate This effect could be driven by a specific carrier or it can potentially be related with the increase The combined effects of both PTMs as well as the relevance of specific acceptor sites and glycan composition

unfavourable situation is that laboratory experiments are performed under highly controlled, abstract, and specific interactions to Gαz and Gαi1, respectively (Figure 2B), as well as different coupling preferences between specific This conundrum for the pharmacologist is analogous to the physicist’s [53] or social scientist’s [54- Hallucinogens recruit specific cortical 5-HT2A receptor-mediated signaling pathways to affect behavior Conformational specificity of opioid receptors is determined by subcellular location irrespective of

Our results show that one specific subset of cross-docking simulations gave results of similar quality Median ligand RMSD values for top-scored poses were 1.2 Å and 2.0 Å for self-docking and StateMatch/FunctionMatch