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276 items found for "T cells"
- Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant
We have now determined heterodimer's Cxcr2 activity using cellular assays and Cxcr2 density in blood proteoglycan Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity
Vanderbilt University, Nashville, TN 37232, USA 4 Peking University, China 5 Department of Anatomy and Cell She oversaw an increase of the size of the Department, as well as a quintupling of its NIH funding, in
- A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection
Therefore, a neutrophil-intrinsic pathway determines their cellular fate, function, and magnitude of Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Session I | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Axel Brunger’s lab at Stanford University to study the structure and function of cell-adhesion proteins which, four papers were published in Nature (2022a, 2022b, 2021, 2020); one paper was published in Cell
- Ep 113 with Dr. Prasenjit Saha
My research goal is to identify novel cellular target receptors of human gut microbe-derived metabolites I was part of a study that identified the receptors of a novel human gut microbe-derived metabolite called , the pursuit of allosteric modulators has gained attention as they have the potential to fine-tune cellular
- Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation
Loss of Gpr101 on macrophages was also associated with a significant disruption in their cellular metabolism Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia
Functional annotation revealed their roles in critical cellular processes such as proliferation and GPCR , leukemia Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
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The policies below, as well as the Dr. GPCR Buttons and Badges guidelines, the Dr. Publishers may not sell or transmit to others any data about a user related to the user's use of any GPCR permission to utilize an automated software program, often called a "web crawler," to retrieve and GPCR Logo in different marketing materials, such as: a new T-shirt design, a toy, software packaging,
- Ep 140 with Dr Alix A J Rouault
This project yielded my first, first author publication in BBA – Molecular Cell Research, and a book
- Ep 27 with Dr. Robert J. Lefkowitz
Well, it’s the one and only Robert J. Before we pressed record, I asked if I could call him Bob, and he answered that only his mom used to call him Robert, especially when she was upset with him. I very much enjoyed chatting with Bob, and I hope you’ll enjoy learning more about him as well. Dr.
- Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis
Using complimentary cellular and biochemical approaches, proteins were tested for effects on GPCR-G α John R Hepler Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 147 with Dr. Demet Araç
Axel Brunger’s lab at Stanford University to study the structure and function of cell-adhesion proteins
- Neutrophils are itching to specialize
Bryan G Yipp Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- The landscape of cancer-rewired GPCR signaling axes
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- Ep 81 with Dr. Christel Menet
I then started my career at Evotec before moving to Domain Therapeutics (called Faust pharmaceutical
- Stable Binding of Full-Length Chemerin is Driven by Negative Charges in the CMKLR1 N-terminus
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- Clinical, pathophysiologic, genetic and therapeutic progress in Primary Bilateral Macronodular Adrenal Hyperplasia
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- Session III | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
It was then adapted for the human aGPCRs CD97/ADGRE5 and Latrophilin/ADGRL3 and tested in HEK293T cells
- Ep 128 with Dr. Ilana Kotliar
study the regulation and protein-protein interactions of GPCRs and a small family of accessory proteins called
- Protease-Activated Receptor-1 IgG Autoantibodies in Patients with COVID-19
Arash Haghikia Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Ep 19 with Dr. Fiona Marshall
As a co-founder of Heptares Therapeutics , now called Sosei Heptares , a GPCR-focused drug discovery
- Ep 148 with Dr Arthur Christopoulos
incorporates computational and mathematical modelling, structural and chemical biology, molecular and cellular long-term support from international and national competitive, charitable and commercial sources, as well Christopoulos has over 360 publications, including in leading international journals such as Nature,Science and Cell global challenges of healthcare workforce growth, climate change, and emerging psychiatric disorders, as well global challenges of healthcare workforce growth, climate change, and emerging psychiatric disorders, as well
- Ep 154 with Dr Badr Sokrat
importance of self-learning, collaboration, and delegation in scientific research, and the need for a well-organized Badr shared his learning process and early tasks at Michelle’s lab, which involved creating stable cell Improving Scientific Communication and Support Yamina and Badr discussed the need for a well-organized
- Ep 149 with Dr Arthur Christopoulos
incorporates computational and mathematical modelling, structural and chemical biology, molecular and cellular long-term support from international and national competitive, charitable and commercial sources, as well Christopoulos has over 360 publications, including in leading international journals such as Nature,Science and Cell global challenges of healthcare workforce growth, climate change, and emerging psychiatric disorders, as well global challenges of healthcare workforce growth, climate change, and emerging psychiatric disorders, as well
- Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5
In conclusion, chemokine N-termini can be mimicked to produce small CCR1-selective agonists, as well pharmacology Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
SCI leads to severe secondary immunosuppression, called SCI-induced immunodeficiency syndrome (SCI-IDS Methods and objectives: The concentrations of adrenocorticotropic hormone and cortisol in plasma, as well Transcriptome Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Aberrant hormone receptors regulate a wide spectrum of endocrine tumors
Hervé Lefebvre Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call
- Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
A GPCR activation process based on the well-discerned conformational states is thus proposed, allosterically micro-modulated by the cation-π lock and a previously well-defined ionic interaction between TM3 and , Libin Ye Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call