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273 items found for "T-cell lymphoma"
- 📰 GPCR Weekly News, December 4 to 10, 2023
G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell neuroscience drugmaker Cerevel Therapeutics for $8.7 billion FDA approves two gene therapies for sickle cell
- Pepducin-mediated G Protein-Coupled Receptor Signaling in the Cardiovascular System
vary between antagonist, partial agonist, and biased agonist outcomes in various primary and clonal cell We will discuss the historic context of pepducin development for each receptor, as well as the structural
- Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated
Here we investigated a potential mechanism for regulation of PLC signaling downstream of MOR in HEK293 cells
- In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
Genetically encoded fluorescent biosensors allow intracellular signaling dynamics to be tracked in live cells
- Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
S1P5 is predominantly expressed in nervous and immune systems, regulating the egress of natural killer cells from lymph nodes and playing a role in immune and neurodegenerative disorders, as well as carcinogenesis
- Propranolol: A “Pick and Roll” Team Player in Benign Tumors and Cancer Therapies
September 2022 "Research on cancer therapies focuses on processes such as angiogenesis, cell signaling
- The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
Several recent studies have demonstrated that TGR5 exerts inconsistent effects in different cancer cells
- 📰 GPCR Weekly News, July 24 to July 30, 2023
Submit a 1-minute abstract video and tell us more about your project using this form. Intracellular calcium ion transients evoked by cell poking independently of released autocrine ATP in Madin-Darby canine kidney cells.
- Pharmacological Properties and Function of PxOctβ3 Octopamine Receptor in Plutella xylostella (L.)
This ORF was also cloned and expressed in HEK-293 cells.
- A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
interaction were conducted, confirming decreased homodimerization capacities of chimeric receptors in HEK293 cells
- Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal...
transduce signals across the plasma membrane and orchestrate a multitude of physiological processes within cells
- Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for ...
: Implications for metabolic regulation G protein-coupled receptors (GPCRs) are a large family of cell
- Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal
previously uncharacterized variants, that exhibit diminished plasma membrane expression in HEK293T cells
- 📰 GPCR Weekly News, January 30 to February 5, 2023
expansion to enable site-specific bioorthogonal labeling of functional G protein-coupled receptors in live cells activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell Discovery Upstream Bio Announces the Appointment of Marcella Ruddy, M.D., to the Board of Directors Call
- Precise druggability of the PTH type 1 receptor
selective small molecules with strong negative allosteric and biased properties for PTHR signaling in cell
- A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands ...
first synthesized a fluorescent ligand enabling equilibrium and kinetic binding studies via NanoBRET as well Applying this molecular tool in a membrane-based setup and in living cells, we discovered a 4-aminopyrimidine
- 📰 GPCR Weekly News, January 8 to 14, 2024
her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in MCF7 breast cancer cells kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells
- Therapeutic validation of an orphan G protein‐coupled receptor
process of de-orphanizing, is of great importance in order to better understanding human physiology as well GPR84 is a Gi‐coupled class A GPCR mainly expressed in immune cells and microglia in the brain (Wojciechowicz Regarding the first question, GPR84 overexpression in immune cells in a range of pro‐inflammatory disorders in respect to tool compounds to study the function of this receptor towards clinical validation, as well In addition, several GPR84 ligands have been described as well as GPR84 knockout mice.
- Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental...
endoplasmic reticulum stress, dysregulated immune tolerance, vascular inflammation and endothelial cell
- Overview of adhesion GPCRs self-activation
Last month a very detailed paper analyzed the molecular mechanisms of the aGPCRs self-activation as well self-activation of aGPCRs, some of which differ from those of GPCRs belonging other families, and I will tell Through cell-based assays and Cryo-EM of high quality, it was possible to know that ADGRL3 can activate Araç, D., et al., A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis Molecular cell, 82(22), 4340–4352.e6.
- 📰 GPCR Weekly News, April 10 to 16, 2023
FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Scientist - Antibody Engineering NEW Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based
- 📰 GPCR Weekly News, May 27 to June 2, 2024
regulates the expression and alternative splicing of genes associated with aphasia-related diseases in PC12 cells Scientist Senior Research Associate/Associate Scientist, Protein Science Post-Doctoral Fellow—Pharmacology/Cell
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that tailors immune cell
- PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
wide array of physiological and disease functions, yet knowledge of their role in colon cancer stem cell A truncated form of β-catenin, ∆N133β-catenin, devoid of lysine, as well as serine/threonine residues
- 📰 GPCR Weekly News, November 20 to 26, 2023
structural conservation across distant species Industry News Avantor's (AVTR) New Offerings to Aid Cell and Gene Therapy Suite Avantor® Expands Cellular Science Offerings with Multispan Cell Engineering and
- 📰 GPCR Weekly News, April 15 to 21, 2024
Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell-derived Updates in GPCR Research Alared: Solvatochromic and Fluorogenic Red Amino Acid for Ratiometric Live-cell
- Phospholipid Scrambling by G Protein-Coupled Receptors
discuss the physiological significance of GPCR scramblase activity and the modes of its regulation in cells
- Design and validation of recombinant protein standards for quantitative Western blot analysis of...
recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor density in cell