Search Results
279 items found for "Tatiana Da Ros"
- Platelets in the NETworks interweaving inflammation and thrombosis
September 2022 "Platelets are well characterized for their indispensable role in primary hemostasis to NETs were also detected in thrombotic lesions in several disease backgrounds, pointing towards a role
- Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response
September 2022 "The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte
- GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization...
intracellular trafficking and targeting process of F-Hst1, in which early endosome plays an important role
- A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
2022 "Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role Recent studies introducing setmelanotide, a novel synthetic MC4R agonist, suggest a predominant role
- Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
recruitment of multiple immunological cells such as microglia, macrophages and monocytes, and play a critical role
- Functional modulation of PTH1R activation and signaling by RAMP2
These data uncover a critical role of RAMPs in the activation and signaling of a GPCR that may provide
- Cholesterol-Dependent Dynamics of the Serotonin 1A Receptor Utilizing Single Particle Tracking....
To explore the role of cholesterol in lateral dynamics of GPCRs, we utilized single particle tracking
- Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
nervous and immune systems, regulating the egress of natural killer cells from lymph nodes and playing a role In this article, we describe a 2.2 Å resolution room temperature crystal structure of the human S1P5
- Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
It plays a key role in the regulation of human calcium and thus mineral metabolism.
- GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
under acute inflammatory stimuli such as lipopolysaccharide (LPS) and TNFα suggests that it may play a role These results define a unique role of GPR84 in innate immune cells and intestinal inflammation, and suggest
- Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR..
Bosentan then slides occasionally from the tip to the root of the N-terminal tail (ligand–sliding). The bosentan-captured conformations by the tip-region and root-region of the N-terminal tail correspond
- Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
Smoothened receptor (SMO, a 7 pass transmembrane domain, Class F GPCR family protein) plays a crucial role cholesterol and other lipid molecules in the ciliary membrane, and to gain molecular-level insights into the role
- Phosphorylation of RGS regulates MAP kinase localization and promotes completion of cytokinesis
G-protein signaling activates the MAPK Fus3, which phosphorylates the RGS; however, the role of this
- Statin-induced increase in actin polymerization modulates GPCR dynamics and compartmentalization
Specifically, we explore the role of actin cytoskeleton in regulating the dynamics of the serotonin1A receptor, a crucial neurotransmitter G protein-coupled receptor (GPCR) that plays a major role in the On a broader perspective, these results assume significance in understanding the modulatory role of the
- Interacting binding insights and conformational consequences of the differential activity of...
Prompted by these results, we investigated the role of the CBD compound on the CB1 receptor using similar
- GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to...
its downstream signaling pathways such as NF-κB, PI3K/AKT, and MAPK/ERK pathways given their critical roles
- FSH and bone: Comparison between males with central versus primary hypogonadism
The present study aims to investigate the possible role of FSH excess in male bone health, by comparing
- PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal...
G-protein-coupled receptor (GPCR), known as Mas-related G protein-coupled receptor-B2 (MRGPRB2), plays important roles
- Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
However, there is no report on the functional role of SK in the Chinese white pine beetle, Dendroctonus The results show that the SK signal pathway plays a positive and significant role in feeding regulation
- PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
(GPCRs) are involved in a wide array of physiological and disease functions, yet knowledge of their role
- Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
Our data reveal the functional role of 5-HT2A–TrkB receptor heterodimerization and suggest that the regulated
- Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
Autophagy deficiency in myeloid cells plays a causal role in eosinophilic CRS (ECRS) via macrophage IL
- Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal...
For this, we explored the possible role of the K101 residue in a cholesterol recognition/interaction
- CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse
During years, several studies have depicted the pivotal role of the cytoskeleton and lipid microdomains responsible for signalling amplification and compartmentalization in T cell activation, focusing on the role
- C3aR plays both sides in regulating resistance to bacterial infections
Specifically, previous research has identified mechanistically distinct and cell type–specific roles In light of these new results, it is imperative that we revisit previous studies regarding the role of Thus, this review will cover specific roles of C3aR in driving cell type–specific and tissue specific
- GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer
September 2022 "GPCRs are the most potential targets for drug discovery, however, their role in oncology
- The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
muscle from both murines and humans, thus representing a potentially significant pathway which plays a role Further research is required to fully delineate their role(s)."
- Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
September 2022 "The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an have shown that certain subsets of T cells express functional GLP-1R, indicating an immune regulatory role the high induction of GLP-1R in human iTreg cells, we hypothesize that GLP-1R+ iTreg cells play a key role