Methods & Updates in GPCR Research 3,4-Bis(hydroxymethyl)hexane-1,6-diol-based Maltosides (HDMs) for

5 - 7, 2024 | 16th Annual PEGS Europe   September 18, 2024 | FREE Webinar - The value of GPCR cell-based

Ligand discovery aimed at identification of chemical tools and drug leads is aided by molecular docking Therefore, docking performance against GPCR targets can be estimated in advance based on docking target

ERK activation pathways can be categorised into two main sub-pathways based on their subcellular localisation

integrated framework combining live cell imaging using confocal microscopy and UMAP-assisted HDBSCAN-based

Strategic Partner Completes Enrollment in ADX71149 Epilepsy Phase 2 Study Part 1 IPO Raises $161M for GPCR-Based

NEW FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

The structural basis for G protein subtype selectivity by these GPCRs remains elusive. mechanism of Gs versus Gi protein coupling selectivity or promiscuity by class A GPCRs and extend the basis

Fluorescent Indicators Design of an effective small expression tag to enhance GPCR production in E. coli-based

blockers   GPCR Events, Meetings, and Webinars September 18, 2024 | FREE Webinar - The value of GPCR cell-based

Greetings, avid readers! Sudarshan Rajagopal, et al. for their finding that GPCR kinases affect biased signaling downstream of CXCR3 based

Molecular Pharmacology GPCR Events, Meetings, and Webinars October 17, 2024 | Unprecedented fragment-based

: John Teye Azietaku for his first contributor article on Illuminating GPCR Research: FRET and BRET-Based

promote neuroregeneration and ameliorate memory loss in rats through cAMP-PKA-CREB signaling pathway based

Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5391-3. doi: 10.1073/pnas.90.12.5391.

discoveries that have advanced our understanding of rod outer segment (ROS) morphology and the pathological basis

providing new opportunities to examine the dynamic fluxes in the 3D architecture of the receptors, as the basis

Employing homology modeling, we describe the putative structural molecular basis underlying our functional

Graeme Milligan and their colleagues research on Pro-phagocytic function and structural basis of GPR84 melanogaster Structural and Molecular Insights into GPCR Function Pro-phagocytic function and structural basis

thalamus (PVT) has recently been identified as an integrator of stimulus salience but the neurochemical basis

pharmacological properties and functions of PxOctβ3 in P. xylostella, thus, providing a theoretical basis

Pharmaceuticals (Basel, Switzerland), 14(5), 439. https://doi.org/10.3390/ph14050439 Chen, K.

This finding reveals a dynamic mechanism for the response of MOR to different ligands and provides a basis

Furthermore, the formation of GPCRs higher order oligomers provides the structural basis for organizing

The structural basis for GPCR activation of down-stream signaling and regulatory proteins; and 4.

Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase.

evolutionary analysis of five fish-specific CCRs (CCR4La, CCR4Lc, CCR12a1, CCR12a2, and CCR12b) in largemouth bass

and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers Structural basis