camelids, have become indispensable tools for interrogating GPCRs both in purified systems and in living cells

Microglia are one of few cell types with a self-contained endocannabinoid system and are positioned at

Endocrinology, and Taste Regulator of G-protein signaling expression in human intestinal enteroendocrine cells , 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based

In CD8 + T cells, the chemokines promote unique transcriptional responses predicted to regulate inflammatory

Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell-derived , 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based

By means of these studies, we developed 14 as a fluorescent CCR2 ligand, enabling cell-free as well as

Opioid receptors are G-protein-coupled receptors (GPCRs) part of cell signaling paths of direct interest

We discuss the importance of understanding the translatability of cell and animal models to have more

Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells 2023) NEW GPCRs in drug discovery: challenges & solutions (June 19 - 23, 2023) Training School on “Cell-based

Translation-independent association of mRNAs encoding protomers of the 5-HT 2A -mGlu2 receptor complex in living cells radiopharma play GPCR Events, Meetings, and Webinars September 18, 2024 | FREE Webinar - The value of GPCR cell-based

Submit a 1-minute abstract video and tell us more about your project in this form. Drosophila homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells GPCRs in Oncology and Immunology A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure

epitope-tagged GCGRs undergo clathrin- and dynamin-dependent endocytosis in HEK293 and Huh-7-Lunet cells

Here, we discovered that the epithelial-cell-derived antimicrobial peptides defensins activated orphan

small molecules that conditionally modulate proteins in their functional state; three-dimensional (3D) cell

G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell neuroscience drugmaker Cerevel Therapeutics for $8.7 billion FDA approves two gene therapies for sickle cell

They participate in the activation, chemotaxis and recruitment of multiple immunological cells such as

nab-paclitaxel has shown clinical activity in advanced TNBC with PD-L1-positive tumor-infiltrating immune cells

vary between antagonist, partial agonist, and biased agonist outcomes in various primary and clonal cell We will discuss the historic context of pepducin development for each receptor, as well as the structural

Here we investigated a potential mechanism for regulation of PLC signaling downstream of MOR in HEK293 cells

Genetically encoded fluorescent biosensors allow intracellular signaling dynamics to be tracked in live cells

Submit a 1-minute abstract video and tell us more about your project using this form. Intracellular calcium ion transients evoked by cell poking independently of released autocrine ATP in Madin-Darby canine kidney cells.

integral to metabolic regulation, particularly in glucose homeostasis and insulin secretion, making it a well-established Cell Metab, 2018. 27 (4): p. 740-756. 3.          Cell, 2016. 165 (7): p. 1632-1643. 6.         

S1P5 is predominantly expressed in nervous and immune systems, regulating the egress of natural killer cells from lymph nodes and playing a role in immune and neurodegenerative disorders, as well as carcinogenesis

September 2022 "Research on cancer therapies focuses on processes such as angiogenesis, cell signaling

This ORF was also cloned and expressed in HEK-293 cells.

interaction were conducted, confirming decreased homodimerization capacities of chimeric receptors in HEK293 cells

transduce signals across the plasma membrane and orchestrate a multitude of physiological processes within cells

previously uncharacterized variants, that exhibit diminished plasma membrane expression in HEK293T cells