Search Results
249 items found for "homology modeling"
- Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa
update on the current knowledge regarding small molecule compounds that have been evaluated as rhodopsin modulators
- 📰 GPCR Weekly News, June 24 to 30, 2024
Networks within Disease-Associated GαS Variants Characterized by an Integrative Biophysical Approach Redox-modulated mechanism of the proton-sensing GPR68 receptor Astrocytic GPCR signaling in the anterior cingulate cortex modulates
- Pepducin-mediated G Protein-Coupled Receptor Signaling in the Cardiovascular System
the intracellular loops of G protein-coupled receptors (GPCRs) that act in an allosteric manner to modulate
- Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota..
roles of the L cell-gut IEL GLP-1R axis, revealing mechanisms linking GLP-1R activation in gut IELs to modulation
- Addex Raises $10 Million In Equity Financing
Therapeutics Ltd (SIX: ADXN and Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based
- GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP
Our results revealed that GB83 is a bona fide agonist of PAR2 that uniquely modulates PAR2-mediated cellular
- Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging...
CB2-related pharmacological and genetic tools, including the first small molecule positive allosteric modulator
- Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
the regulated expression of 5-HT2A and TrkB is a molecular mechanism for the brain-region-specific modulation
- Addex raises $4.2 million in equity financing
Therapeutics Ltd (SIX: ADXN and Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based
- A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands ...
showing that our CCR9-PROTAC is able to reduce CCR9 levels, thereby offering an unprecedented approach to modulate
- Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
prednisolone and/or calcimimetics, (f) the presence of CaSR autoantibodies that operated as biased allosteric modulators
- VAMP2: a crucial player in the delivery of MOR to the synapse
SNARE protein complex in neurotransmitter release has been well characterized, the mechanisms that modulate , which can interact with different fusion proteins and also this different molecular codes will be modulated
- Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent ...
analyses revealed specific LAT-1-positive neurons and first insights into the genetic network that is modulated
- Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of...
Polygalaxanthone III and Pachymic acid, could interact with multiple targets (5-HTR, DR, ADRA, AR, ESR, NR3C1) and modulate
- Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
intracellular cAMP levels can help identify orthosteric agonists and antagonists, as well as allosteric modulators
- HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural ...
of class IB phosphoinositide 3-kinases There is considerable interest in developing antibodies as modulators
- Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent...
axis of PTK2, integrin αIIbβ3, and CIB1 in collagen- and GPVI-dependent thrombus formation, which is modulated
- 📰 GPCR Weekly News, May 13 to 19, 2024
Arthur Christopoulos is now live, titled "A Brief History of Allosteric Modulators." pharmacology Structural and dynamic insights into the activation of the μ-opioid receptor by an allosteric modulator
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the...
Recent evidence indicates that GPR15 may be associated with modulation of the chronic inflammatory response
- Transformative GPCR Insights: Unleash New Horizons in Science | Sep 9 - 15, 2024
., for their groundbreaking work on Positive allosteric modulation of a GPCR ternary complex Unlock Your promotes pressure overload-induced heart failure GPCR Activation and Signaling Positive allosteric modulation
- Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
Consistent with this, transretinal ERG recordings revealed gradual response recovery in moderate background
- GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral...
GPR125 (ADGRA3), an orphan adhesion GPCR, has been shown to modulate planar cell polarity in gastrulating
- GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between ...
as therapeutic targets, considerable focus has been placed on the ability of these therapeutics to modulate
- Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled ...
a much smaller set of G proteins, arrestins, and effectors, activate downstream pathways that often modulate
- 📰 GPCR Weekly News
Industry News Addex and Indivior Extend Research Term Of Substance Use Disorder Gabab Positive Allosteric Modulator
- In vivo metabolic effects after acute activation of skeletal muscle G s signaling
most likely due to the fact that these receptors are also expressed by pancreatic islets where they modulate
- Odorant receptors – a bit of smell for drug discovery
peculiar, and each neuron expresses a single OR gene however, ectopic ORs expression is unlikely to be modulated Due to the diversity of the OR family it will be critical to select potential targets to modulate in
- Phenylalanine 193 in Extracellular Loop 2 of the β 2-Adrenergic Receptor Coordinates β-Arrestin ...
These results provide new insights on the role of the extracellular domain in differentially modulating