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agonist, the eicosanoid 5-oxo-eicosatetraenoic acid (5-oxo-ETE), leads to the formation of filopodia-like elongated projections connecting adjacent cells, known as tunneling nanotube (TNT)-like structures. Altogether, our study pioneers a link between Gi/o-coupled GPCRs and TNT development, and sheds light governing the generation of specialized actin-rich elongated structures in response to bioactive signaling lipids

the underlying cause of many diseases, including type 1 diabetes, obesity, and non-alcoholic fatty liver We further replicated these findings in zebrafish models of islet injury and liver inflammation. zebrafish findings to mammals by showing that macrophages of Ltb4r2-/- mice have defective migration during lipopolysaccharide

: Professor and Chair in Biochemistry (Leipzig, Germany)" Tobias Langenhan on the web Langenhan Lab LinkedIn Synaptamide, an endogenous ligand for GPR110, binds to the N-terminal G-protein autoproteolysis-inducing GPR110 is also highly expressed in the kidney, however, little is known about the function of this receptor Recently, evidence for sex has been described in choanoflagellates, the closest living relatives of animals

Ultra-performance liquid chromatography-mass spectrometry was used for compound separation and characterization Nitric acid (NO) inhibition was tested on the macrophage cell line RAW264.7. Authors Han Zhou, Tao Hou, Aijin Shen, Wenyi Yu, Liangliang Zhou, Wenjie Yuan, Wanxian Wang, Yumin Yao , Jixia Wang, Yanfang Liu, Xinmiao Liang Tags Benign prostatic hyperplasia , G-protein coupled receptor

plays a critical role in transmitting signals inside the body, which is necessary for controlling the life ATP functions as a mighty damage-linked molecular pattern when released outside the cell, accumulating

Upon exposure to the CCR7 ligand CCL19, dendritic cells (DCs) effectively internalize the receptor and ligand as part of the canonical GPCR desensitization response. Such a dual role of CCR7 as a GPCR that both senses and consumes its ligand can thus provide a novel

We detected the expression of GPR37 in NSCLC tissues and cell lines. Authors Han Liu , Yingjie Zhu , Huikun Niu , Jing Jie , Shucheng Hua , Xiaoxue Bai , Shuai Wang , Lei

Subsequently, we selected a compound from a library of backbone cyclic peptides generated toward the

in multiple cancers, and quantitative proteomic and RNA profiling of exosomes in human cancer cell lines

superfamily, had crucial roles in treating infection, inflammation, and tissue damage by binding to their ligands , CCR4Lc, CCR12a1, and CCR12a2 mainly distributed in their extracellular regions, which involved in ligand The potential ligands for these five CCRs were identified by molecular docking analysis, with finding that CCL3 and CCL5 might be the ligands of largemouth bass CCR4La/Lc, and CCL5, CCL8, CCL7, CCL13 and Mingzhu Pan, Eakapol Wangkahart, Qihuan Zhang, Zisheng Wang, Zhitao Qi Tags CCRs , Gene expression , Ligands

Collectively these proteins form a cell surface complex that acts as a recognition platform for Wnt ligands Knowledge of the structural dynamics of this complex is limited and pharmacological and in vivo systems of Neurovascular Signaling, Department of Molecular Biology, ULB Neuroscience Institute, Université libre Beatriz Blanco Redondo on the web Blanco-Redondo Lab LinkedIn Google Scholar X (Twitter) The Adhesion Willem Berend Post on the web Cell Biology LinkedIn < Previous Session Next Session >

U251 glioblastoma cells by enhancing signaling mediated by sphingosine-1-phosphate (S1P), a bioactive lipid

This axis is linked to diseases like HIV/SIV, cancer, and COVID-19. Previous studies of the CXCL16-CXCR6 axis found genetic variation among species but were limited to primates to mammals, turtles, and frogs, while the DRY motif, typical in other CKRs, is found in snakes and lizards sequencing of the lung shows a drop in TRM cells in species with CXCR6 loss, suggesting a possible link

Subsequently, primary ovarian cancer cells derived from ascites and ovarian cancer cell lines were used

SST2 and SST3 reemerged in metastases suggesting conserved receptors genetic potential during tumor life

However, it was unclear how chemokine ligands, activators and antagonists recognize hCCR3, and quantitative A molecular docking study was carried out to investigate how hCCR3 and its ligands work.

revealed that apo-CXCR4 preferentially populates a high-FRET inactive state, while apo-ACKR3 shows little Multiple active-like ACKR3 conformations are populated in response to agonists, compared to the single Much of the conformational heterogeneity of ACKR3 is linked to a single residue that differs between

Authors Ying Bai , Xin Zhang , Jiawei Zhou , Jianqiang Guo , Yafeng Liu , Chao Liang , Wenyang Wang ,

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Thus, OGR1 may be important to limit kidney crystal deposition, which might subsequently be relevant

multiforme (GBM) stands as a formidable challenge in oncology because of its aggressive nature and severely limited Usage of Lorazepam, which has off target agonism of GPR68, is linked to worse clinical outcomes for a This finding was further validated by transmission electron microscopy and liperfluo staining to assess lipid peroxidation. We use U87 and U138 glioblastoma cell lines to show how selective induction of ferroptosis occurs in

Mitochondrial (mt) formyl peptides (FP) activate G-protein coupled receptors (GPCR) like FPR1. mtDNA and heme activate toll-like receptors (TLR9, TLR2/4). GRK2 inhibitors like paroxetine restore functions.

Authors Jessica S Little , Megha Tandon , Joseph Seungpyo Hong , Omar Nadeem , Adam S Sperling , Noopur

expression was significantly higher in the glioma tissues compared to the normal brain tissues, and was linked Functional annotation of GPR37 showed enrichment of ether lipid metabolism, fat digestion and absorption derived foam cell differentiation, negative regulation of T cell receptor signaling pathway, neuroactive ligand Authors Kairong Liang , Zhaoxiong Guo , Shizhen Zhang , Danmin Chen , Renheng Zou , Yuhao Weng , Chengxiang Peng , Zhichao Xu , Jingbai Zhang , Xiaorui Liu , Xiao Pang , Yunxiang Ji , Degui Liao , Miaoling Lai

Peter Gmeiner has been spokesman of the Research Training Group "Medicinal Chemistry of Selective GPCR Ligands . " Peter Gmeiner on the web Friedrich Alexander University Erlangen-Nürnberg Pubmed Google Scholar LinkedIn

The aberrant expression of diverse GPCRs and their ligands play an important role in the over-function

unique junction arrangements where aGPCRs are mainly unexplored. " Monserrat Avila Zozaya on the web LinkedIn

PRL3-zumab humanized antibody Published date September 21, 2023 Abstract "Phosphatase of regenerating liver Hern Wang Cheng , Arjandas Mahadev , Matthew Chau Hsien Ng , Michaela Su-Fern Seng , Prasad Iyer , Pei Ling