designed to assess the kinetics of unlabelled compounds (and chemical fragments) and the use of purified receptor

His interests are in receptor pharmacology, allosteric protein function, and drug discovery. Dr.

large compound libraries with the goal of finding new chemical matter to probe understudied and orphan receptors

adapts interdisciplinary approaches (synthesis, modeling, pharmacology) to study G protein-coupled receptors

His group studies the unusual signaling mechanisms employed by these atypical 7-transmembrane receptors

His main research group centers on the function, structure, and regulation of G protein-coupled receptors

In 2020, he was promoted to a Readership/Professor in Receptor Pharmacology and was elected a Fellow

is currently focused on understanding the signal transduction pathways activated by beta-adrenergic receptors

constrained molecular dynamics simulation methods with emphasis on application to G-protein coupled receptors

Bryan got fascinated with receptors after attending the lecture of a visiting professor on neurotransmission

chemotaxis of activated T cells and natural killer (NK) cells via interaction with its G protein-coupled receptor (GPCR), CXC chemokine receptor 3 (CXCR3).

Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor

During the past 2 decades, my research mainly focused on chemokine receptor structure/function relationships

Nottingham in 2006, where he is now Associate Professor, establishing a lab focused on G protein-coupled receptor

consecutive Wellcome Trust Senior Research Fellowships Andrew established a reputation in the field of receptor

function of important classes of membrane proteins and prominent drug targets, including G protein-coupled receptors

Ray Stevens in 2013 solving several GPCR crystal structures, including that of the first serotonin receptor

modification, and gene expression and to signal extracellularly through binding the G protein-coupled receptor

of Dr Andreas Russ at the Department of Biochemistry and first came across GPCRs, particularly the receptor

his postdoctoral training in Jeff Benovic’s laboratory studying the regulation of G protein-coupled receptor

membership will grant you access to a wealth of resources, research, and discussions on your favorite receptor

This study demonstrates that GPR37, a GPCR receptor, is highly expressed in CRC.

, a corresponding member of the International Union of Basic and Clinical Pharmacology Committee on Receptor

Ljubljana, Slovenia, and at the University of Bonn, Germany, working initially on the role of prostaglandin receptor

Zfhx2, Gpr83, and Chrm2) were enriched in pathways related to inhibitory Gi-mediated G protein-coupled receptor neuroinflammation spreads after injury, and neurotransmission through Gi-mediated G protein-coupled receptors

EVs express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor

Deficiency of SCFA would lead to pro-inflammatory immune cell skewing through insufficient G-protein coupled receptor

his Ph.D. in Neuroscience from Ohio State University focusing on synaptic plasticity and adrenergic receptor