Search Results
279 items found for "Tatiana Da Ros"
- Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
September 2022 "Glutamate is the primary excitatory neurotransmitter in the brain and plays critical roles
- Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
We verified the role of some key residues in the dynamic recognition of naloxone and morphine and identified
- Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge
September 2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine
- Arginine 125 Is an Essential Residue for the Function of MRAP2
The aim of this work was to analyze the functional role of the specific arginine residue at position
- Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...
It has begun to play important roles in drug development for complex diseases such as cancer, including
- Exscientia and Sanofi Establish Strategic Research Collaboration to Develop AI-driven Pipeline ...
upfront cash payment of $100 million with the potential of $5.2 billion in total milestones plus tiered royalties
- Oxford Professor Of Chemistry And Founder Of Therapeutic Company Wins Two International Awards
December 2021 " Dame Carol Robinson DBE, FRS, FRSC, FMedSci, Oxford University’s first female Professor of Chemistry, former president of the Royal Society of Chemistry and Founder of (and ongoing consultant
- Sosei Heptares Announces Antitrust Clearance of License Agreement with Neurocrine Biosciences
Neurocrine Biosciences ”) announced 22 November 2021, the applicable waiting period under the Hart-Scott-Rodino
- Professor Charlotte Deane Joins Exscientia as Chief Scientist of Biologics AI
In this newly created role, she will focus on the application of artificial intelligence (AI), machine She has held numerous senior roles at the University of Oxford , where she is currently Professor of She will maintain both of these roles, in addition to her role at Exscientia . She has played an active role during the COVID-19 pandemic as the UKRI’s COVID Response Director, and
- Septerna emerges with $100M to spark 'second golden age' of prolific drug target GPCR with ...
The company's co-founder, GPCR pioneer and Nobel laureate Robert Lefkowitz , M.D., has 50 years of experience
- Addex Therapeutics To Release Full-Year 2021 Financial Results And Host Conference Call On March 10
Tim Dyer , CEO, Roger Mills , CMO and Robert Lütjens , Head of Discovery Biology, will provide a business
- Targeted Therapies to Reduce Side Effects in Modern Drug Development
they can even dare to contemplate the development of therapeutic options and begin the long, arduous road
- Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84
information, recent developments and use of GPR84 pharmacological tool compounds to study its broader role
- Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1
., 1950 ), also called Duffy-antigen/receptor for chemokines, or DARC ( Novitzky-Basso and Rot, 2012
- Structure Therapeutics Extends Financing, Advances Diabetes and Obesity Clinical Program and...
., today announced it closed an oversubscribed $33 million financing round, extending its $100 million
- RAB-Symposium - Regulatory Autoantibodies Targeting GPCRs. September 15-16, 2022. Lübeck, Germany...
Therefore, the aim of this symposium is to bring together the current knowledge on the role of autoantibodies
- Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
It is a therapeutic target because it plays a role in thermogenesis, lipolysis, and bladder relaxation
- Effects of Small Molecule Ligands on ACKR3 Receptors
characteristics that determine the ability of small molecules to activate ACKR3 receptors, revealing a key role The development of more selective ACKR3 ligands should allow us to better appreciate the unique roles This work will help to better understand the unique signaling roles of ACKR3."
- Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice
August 2022 "Abstract Rodent models are commonly used to evaluate parathyroid hormone (PTH) and PTH-related Divergence, however, in the amino acid sequences of rodent and human PTH receptors (rat and mouse PTH1Rs can lead to differences in receptor-binding and signaling potencies for such ligands when assessed on rodent This introduces an element of uncertainty in the accuracy of rodent models for performing such preclinical
- GPCR Therapeutics welcomes Dr. Ed Brennan as their new Vice President, Head of Clinical Development
He went on to study medicine at the Royal College of Surgeons in Ireland before receiving his Medical
- Neurocrine Biosciences Presents Data on Treatment of Adolescent Patients with Classic Congenital ...
These data will be shared as an oral presentation by Ron S.
- Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
"G protein-coupled receptors (GPCRs) represent a major therapeutic target class as they play a key role
- Domain Therapeutics Raises $42m Series A Financing
Receptors (GPCRs) in immuno-oncology, announced today the closing of a US $42m (€39m) series A financing round
- Targeting the M1 muscarinic receptor in neurodegenerative disease
Conference, a summary of work performed both at Sosei Heptares and Glasgow University characterizing the role
- Trevena Announces Receipt of First $15 million Tranche in Connection with its $40 million ...
2022 Trevena Announces Receipt of First $15 million Tranche in Connection with its $40 million ex-US Royalty-Based central nervous system (CNS) disorders, today announced receipt of the first $15 million tranche from its royalty-based
- Exscientia welcomes Richard J. Law, as their new Chief Business Officer
Exscientia's partnerships and collaborations across pharma and #biotech and is an advocate for the role
- Illuminating the draggable GPCR-ome
Bryan Roth There are 10 open tickets available. Get yours now!
- Trevena Announce Submission of New Drug Application in China for OLINVYK® by its Partner Jiangsu ...
to receive future success payments upon approval and commercialization milestones, as well as a 10% royalty