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352 items found for "Wenmiao Li"
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
The Author(s), under exclusive licence to Springer Nature America, Inc."
- Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice
Thus, OGR1 may be important to limit kidney crystal deposition, which might subsequently be relevant
- Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis
Methods: Patients' data on HCC were sourced from the Liver Hepatocellular Carcinoma-Japan (LIRI-JP) and receptor 1 (HCAR1), 5-hydroxytryptamine receptor 5A (HTR5A) and nucleotide-binding oligomerization domain-like Authors Yuxin Wang , Bao Jin , Xiangan Wu , Jiali Xing , Baoluhe Zhang , Xiaokun Chen , Xiao Liu , Xueshuai
- Ep 101 with Dr Caron Tribute Part 2
GPCR Podcast << Back to podcast list Dr. Caron Tribute Part 2 About Marc Caron Dr. Jie Zhang (1990) Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode
- Ep 49 with Dr. Sudha Shenoy
GPCR Podcast << Back to podcast list Dr. Sudha Shenoy About Dr. Sudha Shenoy Dr. Sudha Shenoy LinkedIn Pubmed Dr. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode
- Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells
Authors Trang T T Nguyen , Wen Lu , Wandi S Zhu , K Mark Ansel , Hong-Erh Liang , Arthur Weiss .
- Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer
., either they are involved in negative regulation of EGFR ligands via the ERAD pathway or positively regulate EGFR ligands via the EGFR signalling pathway. Additionally, different opinions suggest iRhom2 mediated cleavage of EGFR ligands takes place TACE dependently pathways were more observant, specifically MAPK signalling pathways, GPCR signalling pathways, and toll-like
- Ep 99 with Yamina Berchihce
GPCR Podcast << Back to podcast list Dr. Yamina Berchiche About Dr. Yamina Berchiche Dr. Yamina A. developed expertise over the past two decades studying structure/function relationships of GPCRs using live-cell Yamina Berchiche on the web Website LinkedIn Facebook Twitter ResearchGate PubMed Google Scholar Dr. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode
- Ep 116 with Dr. Shivani Sachdev
GPCR Podcast << Back to podcast list Dr. Shivani Sachdev About Dr. Shivani Sachdev "Dr. Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors Shivani Sachdev on the web NIDDK ReseachGate Google Scholar LinkedIn Twitter Dr. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode
- Illuminating Functional Selectivity and Allosterism at GPCRs.
Stéphane Laporte on the web Laporte Lab McGill University LinkedIn Dr.
- Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody
PRL3-zumab humanized antibody Published date September 21, 2023 Abstract "Phosphatase of regenerating liver Hern Wang Cheng , Arjandas Mahadev , Matthew Chau Hsien Ng , Michaela Su-Fern Seng , Prasad Iyer , Pei Ling
- Ep 82 with Dr. Lauren M. Slosky
GPCR Podcast << Back to podcast list Dr. Lauren M. Slosky About Dr. Lauren M. These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling Critically, these ligands reduce addiction-associated behaviors in animal models without the side effects GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode
- Ep 115 with Dr. Paul J. Gasser
GPCR Podcast << Back to podcast list Dr. Paul J. Gasser About Dr. Paul J. Zoology & Physiology at the University of Wyoming, where I studied signaling processes involved in light-induced Gasser on the web Gasser Lab Marquette University Google Scholar ResearchGate LinkedIn Twitter Dr. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode
- Unveiling G-protein coupled receptors as potential targets for ovarian cancer nanomedicines: from RNA sequencing data analysis to in vitro validation
Subsequently, primary ovarian cancer cells derived from ascites and ovarian cancer cell lines were used
- Metabolic crosstalk: Extracellular ATP and the tumor microenvironment in cancer progression and therapy
plays a critical role in transmitting signals inside the body, which is necessary for controlling the life ATP functions as a mighty damage-linked molecular pattern when released outside the cell, accumulating
- Comparative analysis of the occupancy of Histone H3 Lysine 4 methylation in the cells treated with TGFβ and Interferonγ
TGFβ and IFNγ and compare them to explore the genes common to both as well as the specific for each ligand
- Stable Binding of Full-Length Chemerin is Driven by Negative Charges in the CMKLR1 N-terminus
the CMKLR1 N-terminus Published date May 13, 2023 Abstract "The adipokine chemerin is the endogenous ligand of the chemokine-like receptor 1 (CMKLR1), a member of the family of G protein-coupled receptors (GPCR This protein ligand plays an important role in obesity and inflammatory processes. Stable receptor-ligand interactions are highly relevant for its different physiological effects, e. g This may help to develop more potent ligands for the treatment of inflammatory related diseases."
- Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway
However, the interference of density information in signal transduction, which regulates most life activities to cAMP pathway is responsible for transmitting density information, and regulates the key point in life classified as sugar sensor, and intracellular adenylate cyclase (AcyA)-cAMP-PKA pathway that in response to ligands metabolism as well as secondary metabolism, and further affects the growth of A. ochraceus during the entire life Authors Jing Gao, Huiqing Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang Tags Cell communication
- Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation
endogenous role of this pro-resolving receptor in modulating macrophage biology using a novel mouse line This was linked with an increased inflammatory response in the Gpr101 deficient animals and a reduced These observations were linked with a marked dysregulation in peritoneal lipid mediator concentrations novel regulator of both macrophage phenotype and function, modulating key biological activities in both limiting
- Structure-based discovery of functionally selective 5-HT1A receptor agonists
Peter Gmeiner has been spokesman of the Research Training Group "Medicinal Chemistry of Selective GPCR Ligands . " Peter Gmeiner on the web Friedrich Alexander University Erlangen-Nürnberg Pubmed Google Scholar LinkedIn
- Aberrant hormone receptors regulate a wide spectrum of endocrine tumors
The aberrant expression of diverse GPCRs and their ligands play an important role in the over-function
- Ep 29 with Eleonora Comeo
GPCR Podcast << Back to podcast list Eleonora Comeo About this episode Eleonora Comeo is a doctoral candidate We sat down to chat about GPCRs, synthesizing labeled ligands, and her unique position that allows her Eleonora Comeo on the web LinkedIn ResearchGate Pubmed Google Scholar Dr. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode
- Respiratory infections predominate after day 100 following B-cell maturation antigen-directed CAR T-cell therapy
Authors Jessica S Little , Megha Tandon , Joseph Seungpyo Hong , Omar Nadeem , Adam S Sperling , Noopur
- Ep 85 with Nicholas Holliday
GPCR Podcast << Back to podcast list Dr. Nicholas Holliday About Dr. receptor kinetics, signaling, and trafficking and on using novel imaging techniques, such as fluorescent ligands Nicholas Holliday on the web LinkedIn ORCID University of Nottingham Twitter Excellerate Bio Dr. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode
- Ep 146 with Dr Michael Feigin
GPCR Podcast << Back to podcast list Dr. Michael Feigin About Dr. Michael Feigin "Dr. Michael Feigin on the web Roswell Park Feigin Lab Google Scholar LinkedIn Twitter Dr. Thanks for listening to this podcast episode This short survey will help us understand your needs to Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode
- Ep 34 with Dr. Brian Arey
GPCR Podcast << Back to podcast list Dr. Brian Arey on the web LinkedIn ResearchGate Pubmed Dr. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode
- Ep 144 with Dr Aurélien Rizk
GPCR Podcast << Back to podcast list Dr. Aurélien Rizk About Dr. Aurélien Rizk "Dr. Aurélien Rizk on the web InterAx Biotech Paul Scherrer Institut The Org LinkedIn Google Scholar Dr. They highlighted the strategic importance of planning in the biotech sector due to limited funds and Technology Evolution and Ligand Residence Time Prediction Yamina Berchiche and Aurelien Rizk discussed The conversation also revolved around the company's ability to predict the residence time of a ligand
- Pharmacological and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease Pathophysiology
minimize side effects for diet-induced metabolic diseases. " Josh Gross on the web Pubmed Google Scholar LinkedIn