Additionally, using the Gαq/11 inhibitor YM-254890, GPCR kinase 2 and 3 (GRK2 and GRK3) KO cells, and

2023 | ASCEPT Annual Scientific Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

order to avoid interference between these interactions, we studied GRK2 binding in the presence of inhibitors

of antagonists of the tick (Rhipicephalus microplus) kinin receptor identifies small molecules that inhibit

2023 | ASCEPT Annual Scientific Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

review is to present the most important of the aforementioned ligands, highlight their properties and exhibit

Neuropeptides exhibit distinct characteristics which includes their post-translational processing, release

Mutations in VLGR1 have been associated with the human Usher syndrome (USH), the most common form of inherited

Def and Mrgpra2 mutant animals both exhibited skin dysbiosis, with reduced microbial diversity and expansion

SLAS2023 International Conference and Exhibition (February 25 - March 1). (April 20-21, 2023) SLAS Europe 2023 Conference and Exhibition.

| ASCEPT Annual Scientific Meeting NEW February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition Boston Summit NEW May 16 - 19, 2024 | ASPET 2024 NEW May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

Using fluorescently tagged histamine, we explored H2R-histamine binding interaction, which exhibits a

in C. elegans GPCRs in Oncology and Immunology In Silico Design of Novel RGS2-Galpha-q Interaction Inhibitors

In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and

2023 | ASCEPT Annual Scientific Meeting February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

Interestingly, these parameters are altered in cholesterol-depleted cells and the receptor exhibits dynamic

ADS024 is efficacious in multiple neuroinflammatory disease models Discovery of a potent melatonin-based inhibitor

January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

human white blood cells express an average of 160 GPCR mRNAs, ranging from 123 to 206, while platelets exhibit

, the largest family of membrane proteins in eukaryotes and the largest drug target family to date, exhibit

January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

truncated form of β-catenin, ∆N133β-catenin, devoid of lysine, as well as serine/threonine residues, exhibits

February 1 | GPCR Forum ECI February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition February PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

Society International Conference GPCR Events, Meetings, and Webinars SLAS Europe 2023 Conference and Exhibition

O-glycosylation and tyrosine sulfation on CCR5 and CCR1 function In this study engineered cell lines, inhibitors

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PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition