Last month a very detailed paper analyzed the molecular mechanisms of the aGPCRs self-activation as well self-activation of aGPCRs, some of which differ from those of GPCRs belonging other families, and I will tell Through cell-based assays and Cryo-EM of high quality, it was possible to know that ADGRL3 can activate Araç, D., et al., A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis Molecular cell, 82(22), 4340–4352.e6.

FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Scientist - Antibody Engineering NEW Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based

selective small molecules with strong negative allosteric and biased properties for PTHR signaling in cell

first synthesized a fluorescent ligand enabling equilibrium and kinetic binding studies via NanoBRET as well Applying this molecular tool in a membrane-based setup and in living cells, we discovered a 4-aminopyrimidine

endoplasmic reticulum stress, dysregulated immune tolerance, vascular inflammation and endothelial cell

structural conservation across distant species Industry News Avantor's (AVTR) New Offerings to Aid Cell and Gene Therapy Suite Avantor® Expands Cellular Science Offerings with Multispan Cell Engineering and

Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell-derived Updates in GPCR Research Alared: Solvatochromic and Fluorogenic Red Amino Acid for Ratiometric Live-cell

classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that tailors immune cell

wide array of physiological and disease functions, yet knowledge of their role in colon cancer stem cell A truncated form of β-catenin, ∆N133β-catenin, devoid of lysine, as well as serine/threonine residues

depression was involved in the biological process of GPCR signal transduction, hormone metabolism and nerve cell

recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor density in cell

discuss the physiological significance of GPCR scramblase activity and the modes of its regulation in cells

of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells blockers GPCR Events, Meetings, and Webinars September 18, 2024 | FREE Webinar - The value of GPCR cell-based

Comparative interactome analysis of α-arrestin families in human and Drosophila Functional diversification of cell of Gi-coupling receptors via engineered Gt and Nb35 application Imaging GPCR Dimerization in Living Cells

13-coupled designer GPCR GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells Senior Research Associate/Associate Scientist, Protein Science NEW Post-Doctoral Fellow—Pharmacology/Cell

GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for cancer therapy 15, 2023) GPCRs in drug discovery: challenges & solutions (June 19 - 23, 2023) Training School on “Cell-based

evolution of GPCRs, and expand our knowledge of the cladoceran GPCR gene repertories which in part, mediate cell

associated with various cancers, with some members of the RGS family being associated with liver cancer as well < 0.001), RGS20 was found to be an important factor for survival in four other cancers (clear renal cell

ligand-receptor binding by searching large-scale motions accompanied with stable maintenance of the fragile cell-membrane

Here, we demonstrate using various fluorescence imaging approaches at the single cell level to measure

GPR3 After wounding, a G-protein coupled receptor promotes the restoration of tension in epithelial cells glutamatergic neurons GPCRs in Oncology and Immunology TIPE proteins control directed migration of human T cells

to the carboxy region, Smad2 transcription factor can be phosphorylated in the linker region as<br />well Smad2L and protein expression of PAI-1 induced by endothelin-1 (ET-1) in bovine aortic endothelial cells

compartments and their activation is generally related to inhibiting neurotransmission by hyperpolarizing the cell signaling, Shiraki et al., explored the function of β-arrestin 2 in MOR signaling using the SH-SY5Y cell

interactions of the serotonin1A receptor Industry News Neurocrine Biosciences Announces Conference Call in Korea GPCR Events, Meetings, and Webinars September 18, 2024 | FREE Webinar - The value of GPCR cell-based

In ascomycete fungi including yeasts, mating between cells of opposite mating type depends on the molecular

Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell ) Sosei Heptares Receives Approval for Change of Market Listing Segment to the Tokyo Stock Exchange Call

it binds more readily to acetylated histones at promoters and enhancers; moreover, in non-neuronal cells

Scientist Senior Research Associate/Associate Scientist, Protein Science Post-Doctoral Fellow—Pharmacology/Cell