August 2022 "The common mechanisms by which members of the G protein-coupled receptor (GPCR) family respond it is becoming increasingly clear that GPCRs show great diversity in their intracellular location, interacting recent studies on the diversity of location, effectors, and signaling of GPCRs, and how these could interact

Transmembrane Helix 2 Confers Cholesterol-Induced Thermal Stability to the Serotonin 1A Receptor "G protein-coupled receptors (GPCRs) constitute the largest class of membrane proteins that transduce signals across the For this, we explored the possible role of the K101 residue in a cholesterol recognition/interaction

Platelet α-granules contain microbicidal proteins, chemokines and growth factors, which upon release Additionally, platelet interactions with neutrophils enhance neutrophil activation and are often crucial is characterized by neutrophils expelling chromatin fibres decorated with histones and antimicrobial proteins were also detected in thrombotic lesions in several disease backgrounds, pointing towards a role as an interface The negatively charged DNA within NETs provides a procoagulant surface, and in particular NET-derived proteins

GPCR Activation and Signaling Single transmembrane GPCR modulating proteins: neither single nor simple platform Salipro Biotech Expands Global Intellectual Property Portfolio with Granted Patent in Japan Proteros (June 28 - 30, 2023) NEW FREE Seminar Antibodies targeting Membrane Proteins - From Antigen to New Therapeutics I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024) GPCR Jobs NEW Professor in Cardiovascular

August 2022 "Several G-protein coupled receptors (GPCR) are upregulated in Alzheimer's Disease (AD), This article focuses on the role of Aβ granules and their possible interaction with GPCRs that modulate

GPCRs in Cardiology, Endocrinology, and Taste Novel roles for G protein-coupled receptor kinases in cardiac GPCRs in Neuroscience G protein-coupled receptors (GPCRs) as Potential Therapeutics for Psychiatric Disorders Reviews, GPCRs, and more Heterotrimeric G proteins regulate planarian regeneration and behavior. Vesicle-associated membrane protein 2 is a cargo-selective v-SNARE for a subset of GPCRs. Research - Senior Scientist, Cell-Based Assay Development Post Doctoral Fellow Research associate in protein

Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery G-protein-coupled receptors The interaction between two receptors in a dimer involves a conformational change in the transmembrane GPCRs dimers exist in a transient state however they are still able to be activated and interact with G proteins and therefore preserve their physiological functions, an important observation when considering GPCR drugs efficacy usually depends on a pathway (G protein or β-arrestin), whereas side effects are

October 2022 "The canonical model for G protein-coupled receptors (GPCRs) activation assumes that stimulation of heterotrimeric G protein signaling upon ligand binding occurs solely at the cell surface and that , this model has been extended by discovering that some internalized GPCRs continue to signal via G proteins

Sakmar , Vladimir Katanaev , Helen Su , et al. for their fantastic work on Germline mutations in a G protein GPCR Event Spotlight Discovery on Target’s 19th Annual GPCR-Based Drug Discovery Targeting G Protein-Coupled Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Postdoctoral Position Postdoctoral research position GPCR Activation and Signaling Germline mutations in a G protein between the anti-allodynic effects of fingolimod (FTY720) and desensitization of S1P1 receptor-mediated G-protein

September 2022 "RNA editing is a process by which post-transcriptional changes of mRNA nucleotides alter protein The 5HT2C serotonin receptor, which undergoes 32 distinct RNA-editing events leading to 24 protein isoforms also provide a comprehensive analysis of agonist activation and constitutive activity across all 24 protein

September 2022 " Background and purpose: The interaction of arrestins with G-protein coupled receptors The interaction of arrestins with GPCRs requires both agonist activation and receptor phosphorylation

GPCR Event Spotlight Discovery on Target’s 19th Annual GPCR-Based Drug Discovery Targeting G Protein-Coupled of the Adhesion GPCR Latrophilin-1 controls multiple processes in reproduction of C. elegans The G protein-coupled signaling Roles of the gate loop in β-arrestin-1 conformational dynamics and phosphorylated receptor interaction reveals a role for DNAJC13 in DOR downregulation GPCRs in Cardiology, Endocrinology, and Taste Role of G protein coupled receptors in acute kidney injury Ligand-Dependent and G Protein-Dependent Properties for the

synaptic modulation by α2-adrenergic receptors in auditory neurons GPCRs in Oncology and Immunology G protein-coupled a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein , and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells Reviews, GPCRs, and more Exhibition June 2 - 7, 2024 | Chemotactic Cytokines June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein

Inactivation of a Human Olfactory Receptor Deciphering the role of glycosaminoglycans in GPCR signaling G protein-coupled calcium and cAMP in vivo Cryo-EM advances in GPCR structure determination Visualization of endogenous G proteins on endosomes and other organelles Reviews, GPCRs, and more G protein-coupled receptor (GPCR) gene variants Exhibition June 2 - 7, 2024 | Chemotactic Cytokines June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein

September 2022 "The human sweet taste receptor is a heterodimeric receptor composed of two distinct G-protein-coupled molecular docking and site-directed mutagenesis studies have revealed that the VFT, CRR and TMD of TAS1R3 interact with some sweeteners, including the sweet-tasting protein brazzein. feasibility of producing milligram quantities of hTAS1R2-VFT to further characterize the mechanism of binding interaction

distinct high-affinity sites for succinate in succinate receptor 1/GPR91 Specific pharmacological and Gi/o protein responses of some native GPCRs in neurons Beyond the Nucleus: Plastic Chemicals Activate G Protein-Coupled with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function Interaction Exhibition June 2 - 7, 2024 | Chemotactic Cytokines June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein

August 2022 "Background: Activation of signaling effectors by G-protein coupled receptors (GPCRs) depends Although studies have focused on the G-protein signaling state, the mechanism for β-arrestin signaling

GPCR Event Spotlight Discovery on Target’s 19th Annual GPCR-Based Drug Discovery Targeting G Protein-Coupled Non-Proprietary Name for its First-in-class GPR68 Inhibitor Asengeprast (FT011) AlphaProteo generates novel proteins Pharmacology - The Hauser Group NEW Postdoctoral Scholar – iPSC in cardiac and endothelial cell function NEW Protein Postdoctoral Position Postdoctoral research position Adhesion GPCRs Loss of cardiomyocyte-specific Adhesion G Protein Gain control of sensory input across polysynaptic circuitries in mouse visual cortex by a single G protein-coupled

datasets regarding ligand synthesis and screening, ligand binding assays, signaling assays, cell imaging, protein data is classified and compared; and 3) detection, prediction, or generation (e.g. prediction of a protein Jumper et al., 2021) and RoseTTAFold (Baek et al., 2021) allow the prediction of the 3D structure of a protein GPCR-ligand interactions: ML can predict GPCR-ligand interactions based on input data of protein sequences By analyzing drug-target interactions and disease pathways, AI can identify potential candidates that

concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans Calcium-sensing receptor regulates Kv7 channels via Gi/o protein induced pluripotent stem cell-derived nociceptive-like neurons Methods & Updates in GPCR Research G protein-coupled receptor (GPCR) pharmacogenomics Visualization of endogenous G proteins on endosomes and other organelles

from February 12th to 18th, 2024 GPCR Activation and Signaling Fine-tuning activation specificity of G-protein-coupled receptors via automated path searching Heterotrimeric G protein signaling without GPCRs: the Gα-binding-and-activating downstream of CXCR3 depending on their subcellular localization Investigating selectivity and bias for G protein for the atypical chemokine receptor ACKR3 GPCRs in Cardiology, Endocrinology, and Taste The Role of G Protein-Coupled Exhibition June 2 - 7, 2024 | Chemotactic Cytokines June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein

GPCR Activation and Signaling Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility The cannabinoid receptor 1 antagonist AM6545 stimulates the Akt-mTOR axis and in vivo muscle protein Structural and Molecular Insights into GPCR Function The role of G protein conformation in receptor-G protein selectivity. Deadline February 12, 2023 Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology

forming a vicious cycle with IGF1/IGF1R signaling pathway "There is a potential correlation between G-protein-coupled receptor-associated sorting protein 1 (GASP1) and breast tumorigenesis. enhances malignant behaviors of breast cancer cells and decreases their cellular response to paclitaxel by interacting

model and steered molecular dynamics in uncovering the dissociation kinetics of ligands targeting G-protein-coupled industrial scientific communities involved in kinetics-based drug development have become immensely interested Non-equilibrium molecular simulation approaches are proven to be useful in this purpose. times of the antagonist ZMA241385 and agonist NECA that target the A2A adenosine receptor of the G-protein-coupled receptor (GPCR) protein family.

More specifically, this review covers assays to monitor the canonical G protein signaling pathway (e.g . measuring G protein recruitment/activation, inositol phosphate accumulation, or Ca2+ mobilization), assays to monitor non-canonical G protein signaling (such as arachidonic acid release), assays to monitor

G protein-dependent and –independent signaling pathways and their impact on cardiac function. Interaction of G-Protein βγ Complex with Chromatin Modulates GPCR- Dependent Gene Regulation. Regulation of nuclear factor κB activation by G-protein-coupled receptors. Non-traditional roles of G protein-coupled receptors in basic cell biology. Neutrophil Signaling That Challenges Dogmata of G Protein-Coupled Receptor Regulated Functions.

Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein-coupled GPCRs in Neuroscience GPCR interactions involving metabotropic glutamate receptors and their relevance G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders. Structural and Molecular Insights into GPCR Function Structural insight into an anti-BRIL Fab as a G-protein-coupled The Illuminating the Understudied Druggable Proteome Conference.

Remodeling in the Remote Myocardium of Rats After an Acute Myocardial Infarction by Activating β-Arrestin-2, Protein Their remote myocardia showed increased mRNA and protein levels of collagen I/III with higher levels They also showed higher protein levels of phospho-glycogen synthase kinase-3β (p-GSK3β), as well as total levels of Bcl-2, β-arrestin-2, and protein phosphatase-2 (PP2A). Interestingly, Exendin-4 increased mRNA levels of MnSOD, protein levels of β-arrestin-2 and PP2A, and