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September 2022 GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization protein-coupled receptors (GPCR), endocytosis pathways, extracellular signal-regulated kinases 1/2 (ERK1 The inhibitors of GPCR, ERK1/2, phagocytosis, and clathrin-mediated endocytosis (CME) as well as siRNA Overall, phagocytosis, CME, GPCR, ERK signaling, and S2R/TMEM97 are involved in the internalization of

September 2022 Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer demonstrate that exposure to SFK inhibitors, including dasatinib or knockdown of YES and Src induces ERK Dasatinib-induced ERK activation was completely abolished by exposure to the FDA-approved MEK inhibitor

Dendrite Density, Upregulated PSD95 Expression, and Abnormal Activation of the PI3K/AKT/GSK-3β and MEK/ERK Finally, we found that PI3K/AKT/GSK-3β and MEK/ERK in amygdalae of Adgra1-deficient male mice were aberrantly suppressive role of ADGRA1 in anxiety control and synaptic function by regulating the PI3K/AKT/GSK-3β and MEK/ERK

intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK VIPR2 caused increases in the levels of cAMP and phosphorylated extracellular signal-regulated kinase (ERK Together, these findings suggest that VIPR2 controls breast tumor growth by regulating the cAMP/PKA/ERK Nakazawa , Kotaro Tanimoto , Hitoshi Hashimoto , Yukio Ago Tags Breast cancer , Cell proliferation , ERK

-133 in the presence of VIP decreased the phosphorylation of extracellular signal-regulated kinase (ERK Treatment with the ERK-specific kinase (MEK) inhibitor U0126 and the class I PI3K inhibitor ZSTK474 decreased Our findings suggest that VIPR2 signaling regulates cyclin D1 levels through the cAMP/PKA/ERK and PI3K

further decreased expressions of daf-7 encoding TGF-β ligand, jnk-1 encoding JNK MAPK, and mpk-1 encoding ERK Therefore, exposure to CPPDQ potentially resulted in neurotoxicity by inhibiting TGF-β, JNK MAPK, and ERK The inhibition in JNK MAPK and ERK MAPKs signals in CPPDQ exposed nematodes was further related to alteration