GPR21 couples to the Gq family of G proteins and is expressed in macrophages. Studies of GPR21 knock-out mice indicated that GPR21 may be involved in promoting macrophage migration The aim of this study was to evaluate the role of GPR21 in human macrophages, analyzing (i) its involvement THP-1 cells were activated and differentiated into either M1 or M2 macrophages. Cell migration was detected by the Boyden chamber migration assay, performed on macrophages derived from

September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment We show that through proper calibration, the model captures the macrophage heterogeneity in the tumor

September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation Autophagy deficiency in myeloid cells plays a causal role in eosinophilic CRS (ECRS) via macrophage IL autophagy‐enhancing agent, trehalose, or related sugar compounds, and the underlying mechanism focusing on macrophage Methods We investigated the therapeutic effects of trehalose and saccharin on macrophage IL‐1β production

< GPCR News < GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage migration Macrophages are continuously recruited to tissues during chronic inflammation where they exacerbate or We detected BLT2 expression in bone marrow derived and peritoneal macrophages of mouse models. Transcriptomic analysis of Ltb4r2-/- and WT macrophages suggested a role for BLT2 in macrophage migration Collectively, our results demonstrate that BLT2 mediates macrophage migration during inflammation, which

metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages treatment with β-hydroxybutyrate increased gene expression of GPR109A, CD86, IL1B and NOS2 in U937-derived macrophages transiently silenced, the mRNA expression and secretion of IL-1β, IL-6 and TNF-α were impaired in M1 macrophages Finally, the secretome from siGPR109A M1 macrophages reduced the gene and protein expression of COL1A1 IBD , Metabolite-sensing GPCRs , Metabolomic alterations , Microbiota dysbiosis , Pro-inflammatory macrophages

adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages (LUAD) patients, closely related to their prognosis and positively correlated with tumor-associated macrophages Tags A2aR , Lung adenocarcinoma , Migration , Polarization , Targeted therapy , Tumor-associated macrophages