September 2022 GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response Functional studies showed that GASP1 knockout significantly suppressed malignant properties of breast stimulated GASP1 expression by activating the PI3K/AKT pathway, forming a vicious cycle propelling the malignant Collectively, this study demonstrates that GASP1 enhances malignant behaviors of breast cancer cells

September 2022 CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma However, the effect of CCR9 on salivary adenoid cystic carcinoma (SACC) malignant behavior remains unknown This study aimed to investigate the specific molecular mechanism by which CCR9/CCL25 modulates malignant

Additionally, CXCR4 is expressed by tumor cells in blood malignancies and solid tumors."

< GPCR News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in melanoma is one of the deadliest skin cancers. In melanoma as well as in other cancers, acidification of the tumor microenvironment (= TME, inverse Results indicate that GPR4 is involved in the migration of melanoma cells, especially in the tumor periphery melanoma , migration , pH-GPCR.

Enhanced expression of chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated Collectively, our study identified a previously unknown GPCR-mediated malignant progression and translated

demonstrated that GNAI family genes, specifically GNAI3, were significantly associated with carcinogenesis and malignancy Bianca Tobias William , Chih-Yang Wang Tags G-protein-coupled receptor (GPCR) , genome , glioblastoma , malignancy