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September 2022 GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response Functional studies showed that GASP1 knockout significantly suppressed malignant properties of breast stimulated GASP1 expression by activating the PI3K/AKT pathway, forming a vicious cycle propelling the malignant Collectively, this study demonstrates that GASP1 enhances malignant behaviors of breast cancer cells

September 2022 CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma However, the effect of CCR9 on salivary adenoid cystic carcinoma (SACC) malignant behavior remains unknown This study aimed to investigate the specific molecular mechanism by which CCR9/CCL25 modulates malignant

Additionally, CXCR4 is expressed by tumor cells in blood malignancies and solid tumors."

< GPCR News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in melanoma is one of the deadliest skin cancers. In melanoma as well as in other cancers, acidification of the tumor microenvironment (= TME, inverse Results indicate that GPR4 is involved in the migration of melanoma cells, especially in the tumor periphery melanoma , migration , pH-GPCR.

Immunology Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote OvarianCancer Malignancy

The remarkably higher expression of GPR87 in human malignant tissues compared to the normal healthy ones Therefore, in this review article, the main focus is placed on the oncogenic role of GPR87 in various human malignancies