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Canonical chemokine receptors – scavenging “decoys” Chemokine receptors coordinate cell migration upon heterotrimeric G proteins, which, in turn, activate signaling pathways that ultimately lead to cell migration CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging Scavenging may allow cells to continuously migrate by remaining responsive to chemokines (S. D’Amico et. al 2000), becoming incapable of promoting cell migration, a phenomenon which is likely to

August 2022 "Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular binding site and the Gαi interface attenuate G protein signaling and abolish oxysterol-mediated cell migration

The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation Although less characterized, canonical CKRs have also been shown to not only directly regulate migration CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging Scavenging allows cells to continuously migrate by remaining responsive to chemokines, it dampens the it may interfere with other chemokine receptors which share the ligands and ultimately affect cell migration

< GPCR News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in In this study, we investigated the pH-dependent migration of GPR4 wildtype/overexpressing SK-Mel-28 cells Migration of GPR4 overexpressing SK-Mel-28 cells was enhanced in a range of pH 6.5 - pH 7.5 as compared to controls in the impedance-based electrical wounding and migration assay. In Boyden chamber experiments, GPR4 overexpression only increased migration at pH 7.5 in a Matrigel-free

screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration Abstract "The αLβ2 integrin LFA-1 plays a key role in T-cell adhesion to the endothelial vasculature and migration GPCR)/GPCR-associated proteins and kinases in a HuT 78 T cell line model of LFA-1-stimulated T-cell migration morphology were used to assess the contribution of 1109 genes to LFA-1-mediated T-cell polarity and migration This study therefore uncovers new roles for GPCR/GPCR-associated proteins and kinases in T-cell migration

GPCRs in Oncology and Immunology Gallein, G protein βγ subunits inhibitor, suppresses the TGF-α-induced migration We have previously reported that transforming growth factor-α (TGF-α) induces the migration of human This study aims to determine whether Gβγ subunits regulate the TGF-α-induced migration of HCC HuH7 cells Gallein significantly reduced the TGF-α-induced cell migration. These results strongly suggest that Gβγ subunits act as positive regulators in TGF-α-induced migration