Principles of Pharmacology in Drug Discovery II -   Advanced Methods for the Optimization of Candidate Dynamic nature of G-protein coupled receptors Septerna Secures $150 Million in Series B Financing to Advance

September 2022 "Background G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3 (GRK3) is critical for GPCR signaling. Our genomic analysis showed that GRK3 expression correlated with poor prognosis of gastric adenocarcinoma (GAC) patients. However, GRK3’s functions and clinical utility in GAC progression and metastases are unknown. Methods We studied GRK3 expression in normal, primary, and metastatic GAC tissues. We identified a novel GRK3 inhibitor, LD2, through a chemical-library screen. Through genetic and pharmacologic modulations of GRK3, a series of functional and molecular studies were performed in vitro and in vivo . Impact of GRK3 on YAP1 and its targets was determined." Read more at the source #DrGPCR #GPCR #IndustryNews

of novel medicines for patients with central nervous system (CNS) disorders, today announced it is advancing

Andrew Tobin About Dr. Andrew Tobin Andrew Tobin studied Biochemistry at Queen Mary College, the University of London obtaining Following a post-doctoral period at Bristol Myers Squibb in Princeton USA, Andrew returned to the UK Andrew is also the Director of the Advanced Research Centre (ARC) a collaborative initiative at the University Andrew Tobin on the web University of Glasgow ResearchGate Google Scholar Twitter Dr.

David Sykes " David Andrew Sykes, BSc Hons Pharmacology, MSc Molecular Biology and Biochemistry, PhD

Authors Sun-Hee Hwang , Kevin Andrew White , Bandarigoda Nipunika Somatilaka , Baolin Wang , Saikat Mukhopadhyay