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neuron morphogenesis and shapes chemo- and mechanosensation-dependent behavior in C. elegans via a trans Latrophilins in the nematode Caenorhabditis elegans can also function independently of their seven-transmembrane domain and C terminus (trans function). Here, we show that Latrophilin-1 acts in trans to mediate morphogenesis of sensory structures in the This trans function is physiologically relevant in copulation behavior.

August 2022 "Opioid receptors (ORs) represent one of the most significant groups of G-protein coupled receptor (GPCR) drug targets and also act as prototypical models for GPCR function. In a constant effort to develop drugs with less side effects, and tools to explore the ORs nature and function, various (poly)pharmacological ligand design approaches have been performed. That is, besides classical ligands, a great number of bivalent ligands (i. e. aiming on two distinct OR subtypes), univalent heteromer-selective ligands and bitopic and allosteric ligands have been synthesized for the ORs. The scope of our review is to present the most important of the aforementioned ligands, highlight their properties and exhibit the current state-of-the-art pallet of promising drug candidates or useful molecular tools for the ORs." Read more at the source #DrGPCR #GPCR #IndustryNews

GPCRs in Oncology and Immunology GPR56 signaling pathway network and its dynamics in the mesenchymal transition Thus, based on transcriptomic, proteomic, and phosphoproteomic differential expression data of GPR56 activity, we have constructed a signaling pathway map of GPR56 as may be applicable in mesenchymal transition The map incorporates more than 100 molecular entities including kinases, receptors, ion channels, and GPR56 signaling and mesenchymal transition."

< GPCR News < GPCRs in Oncology and Immunology GprC of the nematode-trapping fungus Arthrobotrys flagrans Here we show in the nematode-trapping fungus, Arthrobotrys flagrans, that both are achieved through a A. flagrans develops adhesive traps and recognizes its prey, Caenorhabditis elegans, through nematode-specific

His experience also includes translating knowledge generated into the selection of targets, screening Milligan has published more than 550 peer-reviewed articles and his research has been cited more than