October 2022 "G protein-coupled receptors (GPCRs) are of considerable interest due to their importance to initiate downstream effector signaling. This review aims to explore the signaling pathways, dynamic structures, and physiological relevance in the cardiovascular system of the three most important GPCR signaling effectors: heterotrimeric G proteins is increasing appreciation for the elegance of the regulatory mechanisms that mediate intracellular signaling

October 2022 "Pepducins are small-lipidated peptides designed from the intracellular loops of G protein-coupled receptors (GPCRs) that act in an allosteric manner to modulate the activity of GPCRs. This review will focus in particular on pepducins designed from protease-activated receptors, C-X-C motif chemokine receptors, formyl peptide receptors, and the β2-adrenergic receptor. , signaling, pathophysiologic consequences, and therapeutic potential for each pepducin class."

October 2022 "Visual phototransduction is the most extensively studied G protein-coupled receptor (GPCR ) signaling pathway because of its quantifiable stimulus, non-redundancy of genes, and immense importance published cryo-electron tomography (cryo-ET) data on the ROS with structural knowledge on individual proteins maintaining the spacing between ROS discs, suggesting a plausible mechanism by which intrinsic optical signals

Caron at Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking , and signaling. His research career has focused on the investigation of the regulation of G protein-coupled receptors signaling mechanisms in health and disease.

Caron at Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking , and signaling. His research career has focused on the investigation of the regulation of G protein-coupled receptors signaling mechanisms in health and disease.

For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling in conjunction with better characterized signaling systems.