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increase their ability to perform, understand, and communicate GPCR pharmacology data analysis to a high

September 2022 Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid receptor-dependent activation of EGFR "Background Fentanyl is an opioid analgesic and is widely used in ovarian evidence has suggested the direct role of fentanyl on cancer, little is known on the effect of fentanyl on ovarian Methods Proliferation, migration and apoptosis assays were performed in ovarian cancer cells after fentanyl

September 2022 Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Here, we report that the Ovarian Cancer G-Protein Coupled Receptor1 (OGR1 or GPR68) has dual roles in

October 2022 High hedgehog signaling is transduced by a multikinase-dependent switch controlling the Moreover, in the presence of very high levels of HH, the second effect of FU leads to the local enrichment

Our earlier transcriptomic analysis identified Urothelial Carcinoma Associated-1 (UCA1) as an LPA-stimulated elevated expression of UCA1 enhances cell proliferation, invasive migration, and therapy resistance in high-grade serous ovarian carcinoma cells, whereas silencing UCA1 reverses these oncogenic phenotypes. Bhattacharya , Priyabrata Mukherjee , Ciro Isidoro , Yong Sang Song , Danny N Dhanasekaran Tags GPCR , High Grade Serous Ovarian Carcinoma , Let-7 miRNAs , Oncogenic Pathways , Ovarian Cancer , Therapy Resistance

overexpression of protease-activated receptor 2 (PAR2), a GPCR member in the fallopian tubes (FTs) of high-risk FTs, the origin of ovarian cancer, are known to express genes of serous tubal intraepithelial carcinoma (STICs), a precursor lesion of high-grade serous carcinoma (HGSC). PAR2 expression in FTs may serve as an early prediction sensor for ovarian cancer. serve as a powerful medicament in STICs and ovarian cancer.

Malignancy Published date November 25, 2024 Abstract "The accumulation of ascites in patients with ovarian We show that ovarian cancer cells exposed to ascitic shear stresses display heightened G protein-coupled , ascitic currents , epithelial to mesenchymal transition (EMT) , fluid shear stress , glycocalyx , high grade serous ovarian cancer , mechanotransduction , mucin 15 (MUC15) , transcoelomic metastasis Source