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Thank you for your interest in the Applying Pharmacology to Drug Discovery course with Dr.

- Appreciating the practical realities, limitations, and tradeoffs of GPCR data analysis. , and communicate GPCR pharmacology data analysis to a high level, as well as expertise that can be applied Save 25% on your registration by signing up before April

of PAR2 that induces unique cellular signaling, distinct from trypsin and PAR2-activating peptide (AP delayed and sustained manner compared to the rapid and transient signals induced by trypsin and PAR2-AP Interestingly, unlike PAR2-AP, GB83 and trypsin induced sustained receptor endocytosis and PAR2 colocalization

February 2022 Trevena Announces Submission of New Drug Application in China for OLINVYK® by its Partner IV morphine, conducted in China by Nhwa Trevena is eligible to receive future success payments upon approval that China’s National Medical Products Administration (NMPA) has accepted submission of a New Drug Application of a Phase 3 bridging trial for OLINVYK (oliceridine) injection, a novel IV analgesic that has been approved

Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's In vivo, we found that inhibition of GRP78-ATF6-CHOP apoptosis signaling improved ESS symptoms, and the apoptosis, and the effect depended on the interaction between GRP78 and β-arrestin2. in the pathogenesis of pSS and that β-arrestin2 encourages inflammation-induced epithelial apoptosis through GRP78-ATF6-CHOP apoptosis signaling.

We subsequently created a ranking of high scoring GPCRs, using a multi-objective approach (Pareto Front Our approach was confirmed by re-discovery of established cancer targets such as the LPA and mGlu receptor B J , Gorostiola González M , Wang X , van Vlijmen HWT , Jespers W , Gutiérrez-de-Terán H , Ye K , IJzerman AP , Heitman LH , van Westen GJP.

Further, I applied to create a scientific session at the American Physiology Summit (APS) 2024 dedicated Our session was picked up by the APS.

Stimulation of muscarinic receptors induced strong nuclear translocation of NFAT and NFκB and activated AP