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August 2022 TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment "Background: Inflammatory microenvironment promotes odontoblastic differentiation in this study, we aimed to explore the role of TAS2R in odontoblastic differentiation of hDPSCs in the inflammatory Methods: Microarray analysis was performed to explore the differential mRNA profiles in inflammatory

GRK2/β-arrestin2 play multiple roles in the pathological mechanisms of a wide range of diseases including heart failure, cancer, and inflammatory diseases. in immune cell function and focuses on the pathological implications of GRK2/β-arrestin2 in various inflammatory diseases."

The fact that GPR84 expression in leukocytes is remarkably increased under acute inflammatory stimuli such as lipopolysaccharide (LPS) and TNFα suggests that it may play a role in the development of inflammatory and fibrotic diseases. GPR84 activation imposes pro-inflammatory properties in colonic macrophages through enhancing NLRP3 inflammasome GPR84 antagonist discovered by us, suppresses colitis by reducing the polarization and function of pro-inflammatory

Oncology and Immunology CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases Published date April 20, 2023 Abstract " The CC chemokine receptor 6 (CCR6) is a G protein-coupled This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multiple are involved in the spread of inflammatory response. This review highlights the potential as a therapeutic target of the CCR6 receptor in numerous diseases

diseases and cancers Published date March 15, 2023 Abstract " C-X-C motif chemokine receptor 2 (CXCR2 ) is G protein-coupled receptor (GPCR) and plays important roles in various inflammatory diseases and cancers, including chronic obstructive pulmonary disease (COPD), atherosclerosis, asthma, and pancreatic diseases and cancers. (COPD) , Coronavirus disease 2019 (COVID-19) , Inflammatory disease.

Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory Administration of ITA protects against inflammatory diseases and blockade of ITA production enhances diseases and cancer." Authors Dan Ye , Pu Wang , Lei-Lei Chen , Kun-Liang Guan , Yue Xiong Tags IRG1/ACOD1 , cancer , inflammatory diseases , itaconate Source Contribute to the GPCR News Coming soon Become a Contributor Classified