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Recent studies in experimental animals have shown that certain subsets of T cells express functional In contrast, less is known about the expression and function of the GLP-1R in human T cells. Here, we provide evidence that activated human T cells express GLP-1R. Analysis of CD4+ T cells activated under T helper (Th) 1, Th2, Th17 and regulatory T (Treg) cell differentiation GLP-1R in human CD4+ T cells.

October 2022 GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to of synovial fluid and peripheral blood were analyzed for CD45+CD3+CD4+GPR15+ and CD45+CD3+CD8+GPR15+ T Statistical analysis included Kruskal-Wallis test, T-test, or Mann-Whitney U test, according to data The frequencies of CD4+/CD8+ GPR15+ T lymphocytes are higher in RA patients comparing with healthy subjects Also, the frequency CD4+/CD8+ GPR15+ T lymphocytes are higher in synovial fluid of established RA patients

Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T anti-inflammatory actions of GLP-1RAs require the gut IEL GLP-1R to selectively restrain local and systemic T effects are mediated by the suppression of gut IEL effector functions linked to the dampening of proximal T

Author Kenneth T Bogen Tags Asbestos , Cytotoxicity , Inflammation , Lung cancer , Mesothelioma , Mutation

Kenneth A. Jacobson About Dr. Kenneth A. Jacobson Kenneth A. Kenneth A. Jacobson on the web NIDDK Web of Science Google Scholar LinkedIn Twitter Dr.

RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T and migration Published date November 28, 2024 Abstract "The αLβ2 integrin LFA-1 plays a key role in T-cell cell line model of LFA-1-stimulated T-cell migration. and provides potential novel targets for modulation of the T-cell immune response." Authors Antje Haap-Hoff, Michael Freeley, Eugene Dempsey, Dara Dunican, Emily Bennett, Denise Triglia